Ajinomoto Co., Ltd.

Takeda Pharmaceutical Company Limited

Shingo Makino

Nobuyasu Suzuki

Masahiro Murata

Toshihiko Yoshimura

Eiji Nakanishi

Hiroyuki Izawa

Takashi Tsuji

Kazuyuki Sagi

Yuko Satake

Tatsuya Okuzumi

Akira Chiba

Yasuhiro Tanaka

Manabu Suzuki

Masataka Shoji

Chieko Ejima

Mitsuhiko Kojima

Hiroshi Yamamoto

Hideki Matsumoto

Naoyuki Fukuchi

Tadakiyo Nakagawa

Munetaka Tokumasu

Ryota Yoshimoto

Takashi Kayahara

Sayaka Asari

Masaru Takayanagi

Shinichi Fujita

Tetsuo Yano

Shunji Takehana

Itsuya Tanabe

Toshiki Murata

Youji Yamada

Masaki Hashimoto

Harumi Arisaka

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin. 

Phenylalanine derivatives

The present invention relates to a compound represented by the formula: wherein

Thienopyrimidone compound

Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the &#x3b1; 4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which &#x3b1; 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sj&#xf6;gren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7. 

Piperidine derivative

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin.

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin 

Phenylalanine derivatives of the following formulae and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin 

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1; 4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1; 4 integrin.

Aminoisoquinoline derivatives of the following formulae or analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an excellent effect of inhibiting activated blood-coagulation factor X, and they are useful as anticoagulants or agents for preventing or treating thrombi or emboli.

Aminoisoquinoline derivatives

The present invention also relates to a method of using these novel materials, and other materials, to treat or prevent a disease caused by serotonin or a method of treating or preventing platelet aggregation. The compounds used are piperidine derivatives having the formula (I): ##STR1## wherein the various substituents are defined below.

Piperidine derivatives and anti-platelet agents containing the same

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Kawasaki, Japan

Shingo Makino