Kabushiki Kaisha Toshiba

Shingo Kasai

Ikuo Uematsu

Ichiro Tono

Tomohiro Takase

Kayoko Oomiya

Isao Nawata

Tsutomu Honjoh

Yuriko Oyama

Hideo Eto

Takeshi Yamauchi

Isamu Nitta

Masaaki Hirakawa

Takaaki Wada

Masami Hirata

Tadahiro Nakayama

Kenichi Uchiyama

Isao Kishimoto

Masatoshi Sakai

Masanori Sugitani

According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide.

Measuring system using optical waveguide, measuring device, measuring method, optical waveguide type sensor chip, and magnetic fine particle

An optical-waveguide sensor chip includes an optical waveguide having a first substance immobilized on the surface thereof, the first substance being specifically reactive with an analyte substance, and fine particles dispersed on the optical waveguide and having a second substance immobilized on the surface thereof, the second substance being specifically reactive with the analyte substance.

Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor

An optical sensor () includes a sensor chip member () having an optical waveguide layer (), a combination of an incidence end grating () and an output end grating () spaced from each other, in contact with the optical waveguide layer (), and a reaction reagent () provided on the optical waveguide layer () to detect as an optical change a quantity of measurement object interposed between the incidence end grating () and the output end grating (), and a chamber member () to have, when the sensor chip member () is assembled, a facing surface (F) in position facing the optical waveguide layer (), and a gap (I) defined between the optical waveguide layer () and the facing surface (F), the reaction reagent () being disposed in the gap (I).

Optical sensor

An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt.

Optical waveguide type antibody chip and method of measuring antigen concentration

A method of preparing a coating solution for a glucose sensing membrane, the method comprising preserving a first solution containing an oxidizing enzyme or a reducing enzyme of glucose and a reagent for generating a substance for coloring a coloring agent dissolved in a buffer solution, preserving a second solution containing a mixed solution of an alcohol solution of the coloring agent and a solution of a membrane-forming polymer compound, and mixing the first solution and the second solution.

Coating solution for glucose sensing membrane and method of manufacturing optical glucose sensor chip

The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical waveguide layer, which comprises immobilizing the measuring object and an enzyme-labeled antibody labeled with a labeling enzyme on the antibody immobilized layer of the sensor chip having an immobilized antibody, producing a color-developing and precipitating enzyme reaction product by allowing to react a coloring reagent with the labeling enzyme on the antibody immobilized layer to precipitate the enzyme reaction product on the antibody immobilized layer, allowing to totally reflect a light impinged on the sensor chip from the outside at an interface between the optical waveguide layer and the antibody immobilized layer, and observing to a physical value of the totally reflected light.

Concentration measuring method, concentration measuring kit, and sensor chip for use in the method

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Yokohama, Japan

Shingo Kasai