Asahi Glass Company, Limited

Kaken Pharmaceutical Company, Ltd.

Shin Teradaira

Takahiko Murata

Yasushi Matsumura

Masahiro Amakawa

Katsuhiko Konishi

Provided is a compound represented by the formula (1): wherein Rand Rare each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1-3, Ris a hydrogen atom, an alkyl group having a carbon number of 1-4, an alkoxyalkyl group, an aryl group, a halogen atom or a haloalkyl group, or a pharmaceutically acceptable salt thereof, which has, unlike known PGIanalogs, a selective EP4 agonist action, and a medicament containing the compound, which is useful for the prophylaxis and/or treatment of immune diseases, diseases of the digestive tract, cardiovascular diseases, cardiac diseases, respiratory diseases, neurological diseases, ophthalmic diseases, renal diseases, hepatic diseases, bone diseases, skin diseases and the like.

EP4 agonist

Provided is a compound represented by the formula (1): wherein Rand Rare each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1-3, Ris a hydrogen atom, an alkyl group having a carbon number of 1 -4, an alkoxyalkyl group, an aryl group, a halogen atom or a haloalkyl group, or a pharmaceutically acceptable salt thereof, which has, unlike known PGIanalogs, a selective EP4 agonist action, and a medicament containing the compound, which is useful for the prophylaxis and/or treatment of immune diseases, diseases of the digestive tract, cardiovascular diseases, cardiac diseases, respiratory diseases, neurological diseases, ophthalmic diseases, renal diseases, hepatic diseases, bone diseases, skin diseases and the like.

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Kyoto, Japan

Shin Teradaira