Kowa Company Limited

Shin Tanikawa

Shinsuke Itoh

Takahisa Ogamino

Yoshiharu Miyake

Yukiyoshi Yamazaki

Hiroyuki Ishiwata

Ayumu Okuda

Yoshikazu Sawada

Tomoaki Fukuda

Okihisa Tokuda

The present invention is to create a compound that selectively activates glucokinase in the liver, and in particular, to provide an agent for treating and preventing diabetes and impaired glucose tolerance, wherein the agent has a low hypoglycemia risk. A compound represented by the formula (1) as shown below, or a salt thereof, or a solvate of the compound or the salt: wherein, in the following formula (1), ring A represents a thiazolyl group, a pyridyl group, a pyrazyl group, or a pyrazolyl group; L represents &#x2014;(CO)&#x2014;, &#x2014;(CS)&#x2014;, or &#x2014;SO&#x2014;; and Rrepresents a Calkyl group, a hydroxy Calkyl group, a Calkoxy group, an amino group, a Calkylamino group, a hydroxyamino group, an N&#x2014;Calkylcarbamoyl group, or a group represented by the formula (2) as shown below, wherein Rrepresents a Calkyl group; and Rrepresents a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, or a carboxyl group. The formulas are shown below: 

Phenylacetamide compound and pharmaceutical containing same

The present invention provides a novel compound represented by a general formula (1) as shown below, which has a glucokinase-activating action in the liver and pancreatic &#x3b2;-cells and which is useful as an agent for preventing and/or treating diseases caused by hyperglycemia, such as diabetes. A spiroindoline compound represented by the general formula (1), or a salt thereof, or a solvate of the compound or the salt: [wherein ring A represents a nitrogen-containing 5-10 membered heteroaryl group;Rand R, which are the same or different, each represent a hydrogen atom, a halogen atom, a halo Calkyl group, a Caryl group, a cyano group, a Calkyl group optionally having a substituent, a Calkenyl group optionally having a substituent, etc.; Rrepresents a hydrogen atom, a Calkyl group optionally having a substituent, etc.; and Rrepresents a hydrogen atom, a halogen atom, a Calkyl group optionally having a substituent, etc.]

Spiroindoline compound, and medicinal agent comprising same

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Tokyo, Japan

Shin Tanikawa