Daiichi Pharmaceutical Co., Ltd.

Snow Brand Milk Products Co., Ltd.

Shin Nomoto

Masamichi Nakakoshi

Susumu Ishiguro

Yoshikazu Ikeda

Motohide Seya

Masayuki Okue

Shin'ichi Shimada

Rolf Wolfgang Hartmann

Makoto Yoshihama

Yasuyoshi Takeshita

Shinichi Shimada

Yuzo Yagi

Noboru Kawaguchi

Nobuo Ogane

Tadayoshi Koyama

Noriko Abe

Ken'ichi Kimura

Bertil Wachall

Naomi Kito

Junji Nakamura

Kunio Tomitsuka

Takeko Takada

Yasunari Saito

Hiroshi Nakamura

Noboru Kwaguchi

Benzofuran derivatives

Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C -lyase inhibiting activity, thromboxan A synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.

Dihydronaphthalene compounds

Particular hexahydropyrano [3,2-b] [1,4] benzothiazine derivatives represented by the following general formula (I) or pharmaceutically acceptable acid-addition salts thereof. ##STR1## The compounds can facilitate the metabolic turnover of inositol phospholipids at a hippocampus playing an important part in memory, and improve cerebral function leading the memory. The compounds can be utilized as agents for activating brain metabolism and improving cerebral function.

Hexahydropyrano [3,2-B] [1,4] benzothiazine derivative

The invention provides novel compounds and salts thereof, have the structure ##STR1## wherein R.sub.1 is a guianidinobenzoyloxy group and R.sub.2 is a hydrogen atom, a hydroxy, cyano, --COR.sub.3 (wherein R.sub.3 is an amino or lower alkyl group) or --COOR.sub.4 group [wherein R.sub.4 is a hydrogen atom, lower alkyl, phenyl, benzyl or --CH.sub.2 CONR.sub.5 R.sub.6 group (wherein R.sub.5 and R.sub.6 are the same or different and selected from a hydrogen atom and lower alkyl groups)], and wherein R.sub.1 is a hydroxy group and wherein R.sub.2 is a --COR.sub.3 (wherein R.sub.3 is an amino or lower alkyl group) or --COOR.sub.4 group [wherein R.sub.4 is a (C.sub.1, C.sub.3 or C.sub.4) alkyl, phenyl, benzyl or --CH.sub.2 CONR.sub.5 R.sub.6 group (wherein R.sub.5 and R.sub.6 are the same or different and selected from a hydrogen atom and lower alkyl groups)]. The compounds, wherein R.sub.1 is a guanidinobenzoyloxy group, are useful protease inhibitors as anti-trypsin agents.

Isoquinoline derivatives and salts thereof

Growing community of inventors

Kawachi-gun, Japan

Shin Nomoto