Foundation for Biomedical Research and Innovation at Kobe

Foundation for Biomedical Research and Innovation

Shin Kawamata

Yoshiki Sawa

Hoshimi Kanemura

Masahiro Go

Naoki Nishishita

Satoru Sakakida

Shinya Fukui

Yoshinobu Murakami

Hirokazu Hirata

The invention provides a method of removing or reducing undifferentiated cells from a differentiated cell population contaminated or having a risk of contamination with undifferentiated cells by contacting a pigment epithelium-derived factor with the differentiated cell population to induce apoptosis of the undifferentiated cells. The invention also provides an agent for cell transplantation therapy, containing a differentiated cell population substantially free of an undifferentiated cell, which is obtained by the method, as well as an agent for inducing apoptosis of an undifferentiated cell, containing a pigment epithelium-derived factor, and combined use of the aforementioned agent for cell transplantation therapy and the aforementioned agent for inducing apoptosis.

Cell sorting method

The present invention provides a method of treatment for ischemic heart disease administering a scar formation accelerator containing at least one selected from SFRP2, SFRP4, Midkine, Pleiotrophin and Thymosin beta-10 as an effective ingredient to promote scar formation less fibrosis and retaining elasticity, and thereby improving cardiac function.

Method of treatment for ischemic heart disease

Growing community of inventors

Kobe, Japan

Shin Kawamata