Matsushita Electric Industrial Co., Ltd.

Panasonic Corporation

Panasonic Healthcare Holdings Co., Ltd.

Phc Holdings Corporation

Shin Ikeda

Shiro Nankai

Toshihiko Yoshioka

Motokazu Watanabe

Masaki Fujiwara

Tomohiro Yamamoto

Takahiro Nakaminami

Teppei Shinno

Miwa Hasegawa

Yuko Taniike

Yoshinobu Tokuno

Yoshifumi Takahara

Hideyuki Baba

Haruhiro Tsutsumi

Junko Iwata

Mariko Miyashita

Yoshiko Miyamoto

Shigeki Joko

Syoji Miyazaki

Mariko Miyahara

Takahiro Takasu

A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.

Sensor and concentration measurement method

Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (), a counter electrode (), and a blood sample holding part () having branch parts (). A first reagent () consisting essentially of an oxidant in a redox substance is disposed in contact with the surface of a counter electrode which faces the branch part (), and a second reagent () consisting essentially of a reductant is disposed in contact with the surface of a working electrode that faces the branch part ().

Method for measuring hematocrit value of blood sample, method for measuring concentration of analyte in blood sample, sensor chip and sensor unit

Provided is a sensor chip for electrochemically measuring a concentration of an analyte in a blood sample. In one embodiment of the sensor, the sensor chip includes a substrate, and a preliminary measurement analyzer and a hematocrit value analyzer disposed on the substrate. The preliminary measurement analyzer includes a preliminary working electrode and a preliminary counter electrode. The hematocrit value analyzer includes a working electrode and a counter electrode. An oxidant of a redox substance is disposed on the preliminary measurement analyzer and the counter electrode. A reductant of a redox substance is disposed on the working electrode.

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The method of measuring a component in blood using a biosensor comprising a first electrode system including a first working electrode on which at least an oxidoreductase that acts upon the component and a mediator are provided and a first counter electrode and a second working electrode on which the mediator is not provided. The first working electrode and the first counter electrode are used for obtaining the amount of the component and the second working electrode and the first working electrode are used for obtaining the amount of the blood cells.

Method of measuring blood component, sensor used in the method, and measuring device

The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrodemeasures a current that flows during a redox reaction of a blood component, a second working electrodemeasures the amount of blood cells, and a third working electrodemeasures the amount of an interfering substance. Next, based on the measurement results, the amount of the blood component to be measured is corrected. Thus, more accurate and precise measurement of the amount of the blood component can be realized.

Method for measuring blood components and biosensor and measuring instrument for use therein

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system () and a reagent layer (), and the reagent layer () has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode (). The second analysis portion has a working electrode and a counter electrode, and a mediator is provided on the counter electrode but not on the working electrode. In the second analysis portion, a Hct value of the blood is measured by supplying the blood to the electrode system, applying a voltage to cause a current to flow, and detecting a value of the current. Using this Hct value, the amount of the component is corrected.

The present invention provides a method of electrochemically measuring a hematocrit (Hct) value using a sensor, capable of achieving excellent measurement accuracy and reliability and also provides a sensor used in the method. The method of electrochemically measuring a hematocrit (Hct) value of blood include: providing an electrode system having a working electrode () and a counter electrode (), in which a redox substance is provided on the counter electrode () but not on the working electrode (); supplying blood to the electrode system; applying a voltage to the electrode system in this state to cause an oxidation current or a reduction current to flow between the working electrode () and the counter electrode (); detecting the oxidation current or the reduction current; and determining a Hct value based on a value of the detected current.

Method of measuring hematocrit (Hct), sensor used in the method, and measuring device

Growing community of inventors

Katano, Japan

Shin Ikeda