Shionogi & Company Limited

Shin-ichiro Hara

Nobuhiro Haga

Masanao Inagaki

Yoshinori Tamura

Tsuyoshi Hasegawa

Yoshihisa Goto

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein Rand Rare each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., Ris hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., Ris hydrogen or lower alkyl, Ris hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl,or a pharmaceuticallyacceptablyacceptablesalt, or a solvate thereof is provided.

6,7-unsaturated-7-carbamoyl substituted morphinan derivative

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I):

A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein Rand Rare each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., Ris hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., Ris hydrogen or lower alkyl, Ris hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl,or a pharmaceutically acceptably salt, or a solvate thereof is provided.

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Osaka, Japan

Shin-ichiro Hara