Tanabe Seiyaku Company, Limited

Other

Shin-ichi Yamada

Ryuzo Yoshioka

Takeji Shibatani

Hiroshi Fujiwara

Shinji Takamura

Yasuhiko Ozaki

Jun-ichiro Kita

The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-&lsqb;4-&lsqb;(4-chlorophenyl) (2-pyridyl)methoxy&rsqb;piperidino&rsqb;butanoic acid represented by the formula (I):

Acid-addition salts of optically active piperidine compound and process for producing the same

An optically active salt of 1,5-benzothiazepine compound of the formula (I) or (II): ##STR1## wherein each of Ring A and Ring B is a substituted or unsubstituted benzene ring, and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group, can be prepared by resolving a racemic salt of 1,5-benzothiazepine compound of the formula (I) or (II) by means of preferential crystallization.

Optically active benzothiazepine compounds and process for preparing the

An optical resolution process of the compound of the formula (1): ##STR1## wherein Ring A and Ring B are a substituted or unsubstituted benzene ring and R.sup.1 and R.sup.2 are the same or different and a lower alkyl group, by utilizing difference in solubility between the two diastereoisomeric salts prepared by treating the racemic compound (1) with an acidic resolution agent. The present process is industrially advantageous with compared to conventional processes for preparing an optically active 3-hydroxy-1,5-benzothiazepine derivative which are useful as an intermediate for preparing medicines.

Process for preparing optically active 3-hydroxy-1,5-benzothiazepine

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Takarazuka, Japan

Shin-ichi Yamada