Yamanouchi Pharmaceutical Company Ltd.

Shin-ichi Tsukamoto

Toshinari Tamura

Shinji Usuda

Hitoshi Nagaoka

Masatomi Harada

Shuichi Sakamoto

Mitsuo Fujii

Masamichi Okada

Junya Ohmori

Jun-ichi Shishikura

Hiroshi Inami

Masaaki Hirano

Takeshi Murakami

Takayuki Suzuki

Yoshinobu Nagano

Hidenori Iwamoto

Satoshi Hayashibe

Tomoyuki Yasunaga

Minoru Yamamoto

Makoto Yoshida

Kyoichi Maeno

Takenori Kimura

Masao Sasamata

Kazuyuki Hidaka

Takuma Morita

Soichi Kagami

Kazushige Ohno

Takeru Kohinata

Sakiko Tomizawa

Shin-ichi Yatsugi

Tokio Yamaguchi

Kazuhiro Nakato

Kimio Katsuda

Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative

1,2,3,4-tetrahydroquinoxalinedione derivative

Thiophene derivative and pharmaceutical composition thereof

N-(3-pyrrolidinyl) benzamide derivative

Morpholine derivative

Hydrochloride salts of heterocyclic spiro compounds are provided and can be represented by the following general formula: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## alk in which R.sup.1 to R.sub.3,R.sub.6,R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, COOH, or ester, or --C alkyl, R.sub.5 is halo, OH,SH, O alkyl, S alkyl, O acyl or S acyl, and Z, and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Hydrochloride salts of heterocyclic spiro compounds

(-)-(S)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane L-tartrate

Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## in which R.sup.1 to R.sub.3, R.sub.6, R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, --COOH, or ester, or ##STR3## R.sub.5 is halo, OH, SH, O alkyl, S alkyl, O acyl or S acyl, and Z.sub.1 and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Heterocyclic spiro compounds and methods for preparing the same

Heterocyclic spiro compounds represented by the following general formula and salts thereof ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

Substituted azetidinone compounds are provided which have the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 represents a substituted lower alkyl group, an azido group, an amino group, a lower acylamino group, a mercapto group or a lower alkylthio group and the other represents a hydrogen group, or, both represent hydrogen atoms or lower alkyl groups; R.sup.3 represents a hydrogen atom or a group shown by formula: ##STR2## (wherein X represents ##STR3## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group) and Y represents a hydroxy group, a lower alkoxy group, an amino group, a mono- or di-lower alkylamino group); R.sup.4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a group shown by formula: --CH.sub.2 CO--A (wherein A represents an amino group or a group shown by formula: ##STR4## (wherein X and Y are as defined above), provided that when R.sup.1 and R.sup.2 are both hydrogen atoms, at least R.sup.4 represents a group other than a hydrogen atom and provided that either R.sup.3 or R.sup.4 represents a group other than a hydrogen atom. The compounds have strong CNS action.

CNS active substituted azetidinone compounds

Fatty acid derivatives represented by the general formula ##STR1## and salts thereof. The compounds of this invention have excellent fibrinolytic action and a highly improved solubility.

Fatty acid derivatives and process of producing them

Growing community of inventors

Ibaraki, Japan

Shin-ichi Tsukamoto