Daiichi Pharmaceutical Co., Ltd.

Shin-ichi Mochizuki

Eisuke Tsuda

Kanji Higashio

Masaaki Goto

Fumie Kobayashi

Kazuki Yano

Tomonori Morinaga

Nobuaki Nakagawa

Hisataka Yasuda

Masahiko Kinosaki

Kyoji Yamaguchi

Akihiro Tomoyasu

Tadashi Nakakarumai

A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 kD and/or 23 kD under reducing conditions, and exhibiting affinity to heparin. A process of producing the protein comprising culturing human fibroblasts and purifying the culture broth by chromatography using an ion exchange column, affinity column, and reverse phase column. A cDNA encoding the protein and a process of producing the protein using the cDNA are also provided. The protein of the present invention is useful as a pharmaceutical composition for preventing or treating obesity or as an antigen for establishing immunological diagnosis, etc.

Protein and processes for producing the same

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Tochigi, Japan

Shin-ichi Mochizuki