Japan Science and Technology Agency

Shin-ichi Mochizuki

Kazuo Sakurai

Hiromi Morishita

This peptide/&#x3b2;-1,3-glucan complex includes &#x3b2;-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded covalently to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with &#x3b2;-1,3-glucan, forming a complex having a triple helix structure including a single molecular chain of the polynucleotide or derivative thereof and two molecular chains of the &#x3b2;-1,3-glucan. Alternatively, the side chain of the &#x3b2;-1,3-glucan and the antigenic peptide are bonded covalently formed by either a cycloaddition reaction between an alkyne and an azide derivative, or a reaction between a maleimide group or a vinyl sulfone group and a thiol group.

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Kitakyushu, Japan

Shin-ichi Mochizuki