Ono Pharmaceutical Co., Ltd.

Katsuhiko Mikoshiba

Shin-ichi Hamano

Shiro Shibayama

Yoshikazu Takaoka

Hiromu Habashita

Takuya Seko

Akio Nishiura

Ryoji Matsumoto

Takayuki Maruyama

Hirohide Iwasaki

Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein Ris formula (II) or formula (III); Ris alkyl or alkynyl etc.; R, Ris H, (substituted) alkyl etc., or Rand Rtogether to form formula (IV); Ris H or alkyl). Therefore the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.

Triazaspiro[5.5]undecane derivative and pharmaceutical composition comprising the same as active ingredient

An intracellular calcium concentration increase inhibitor containing as the active ingredient (1) a boron compound represented by the formula (I).  The compound represented by the formula (I) inhibits the increase of the intracellular calcium concentration, and therefore it is deemed to be useful as an agent for the prophylaxis and/or treatment of platelet aggregation, ischemic diseases in hearts and brains, immune deficiency diseases, allorgosis, bronchial asthma, hypertension, cerebrovascular spasm, various renal diseases, pancreatitis, Alzheimer's disease, etc.

Intracellular calcium concentration increase inhibitors

Triazaspiro[5.5]undecane derivatives, quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as an active ingredient.  So the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.

Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient

Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient

Prostaglandin E.sub.1 ester derivatives of the formula (I): ##STR1## wherein the R' groups are the same as each other and are C4-12 alkyl; or cyclodextrin clathrates thereof, liposome formulations containing them, and pharmaceutical compositions containing them, as active ingredient. The compounds of formula (I) have the effect of increasing blood flow and are useful for the prevention and/or treatment of peripheral circulatory disorder, decubitus, or skin ulcers, or for the maintenance of blood flow.

Prostaglandin derivatives

Prostaglandin E, ester derivatives of the formula (I): ##STR1## wherein R is (i) --CH.sub.2 CH.sub.2 --O--CO--R.sup.1

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Osaka, Japan

Shin-ichi Hamano