Mogam Institute for Biomedical Research

The Green Cross Corporation

Shin A Jang

Mi Jung Lee

Dong-Sik Kim

Eun Jung Song

Jae Chan Park

Jong Wha Won

Hye-Ji Choi

Ae Rin Yoon

Ok Jae Lim

So Jung Lim

Jee Won Lee

Sung Keun Kim

Hyun Jung Cho

Gil-Jung Kim

Mun Kyung Kim

Su A Lee

Hae Naem Kwon

Mi Young Oh

Jae-Chul Lee

A bispecific anti-GPNMB/anti-CD3 antibody specifically binds to CD3 (cluster of differentiation 3) and GPNMB (glycoprotein non-metastatic melanoma protein B) and uses thereof are disclosed. The bispecific antibody shows high affinity and specificity to CD3 and GPNMB and thus can induce death of cancer cells expressing GPNMB and inhibit proliferation thereof. Therefore, the bispecific antibody can be used as an effective therapeutic agent for cancers expressing GPNMB.

Bispecific antibody specifically binding to GPNMB and CD3, and use thereof

The present invention relates to a novel antibody library and an antibody-screening method using same. Having a human sequence-derived specific VH or VL scaffold, the antibody library according to the present invention exhibits high thermodynamic stability and enjoys the advantages of allowing high soluble expression as well as reversible folding. In addition, the antibody according to the present invention includes a variety of rationally controlled CDRs so as to exhibit high specificity and high affinity to all antigens and thus can be advantageously used for selecting an adequate candidate antibody against a target antigen.

Antibody library and antibody screening method using same

Growing community of inventors

Yongin-si, South Korea

Shin A Jang