Kracie Holdings, Ltd.

Shimpei Watanabe

Satoshi Inamasu

Mitsuhiro Watanabe

Yoko Takashina

Yuichi Takajo

Akiko Ohno

Satoshi Yomoda

Ayako Arai

Yuko Kitahara

Taisaku Kanatani

[Problem] To provide a novel medicine that is capable of promoting cholesterol metabolism to thereby treat, ameliorate or prevent various symptoms associated with increase in blood cholesterol level. [Solution] The present inventors newly found that arctigenin has an effect of promoting the conversion of cholesterol into bile acid. The present invention provides a bile acid synthesis promoter, a composition for promoting bile acid synthesis and a food composition for promoting bile acid synthesis each comprising arctigenin and/or arctiin as active ingredient(s).

Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis

To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1&#x3b2; released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.

Inhibitor of inflammasome activation

Growing community of inventors

Tokyo, Japan

Shimpei Watanabe