Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Hadasit Medical Research Services and Development Ltd.

Other

Institut National De La Sante Et De La Recherche Medicale

Fox Chase Cancer Center

Shimon Gatt

Yechezkel Barenholz

Herve Bercovier

Arie Dagan

Shimon Slavin

Zvi Eldar

Rivka Cohen

Yechezkel Barenholtz

Rene Santus

Gideon N Harnoy

Edward L Engelhardt

Danielle Hirsch-Lerner

Jeremy Zahavy

Arieh Dagan

Jeremy Zahavi

J Donald Chapman

Jean-Claude Maziere

The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

Synthetic analogs of sphingolipids

The extent of binding of a moiety, such as a biomolecule, to a surface, where the local environment at the surface has a pH or surface potential which is altered upon binding of the moiety, is determined by stably incorporating at the surface a probe which contains a pH- or potential-sensitive fluorophore.

Detection of binding of charged species using PH- or potential-sensitive probes

Sphingolipids

The invention provides a moist, absorbent material for cleaning articles and surfaces, wherein the material is moistened with an aqueous solution containing liposomes having vesicles of a diameter of up to about 100 nm.

Moist, absorbent material for cleaning articles and surfaces

The invention provides a method for cleaning the surfaces of a motor vehicle which is contaminated with wastes containing organic or lipophilic deposits, comprising applying liposomes thereto, which liposomes modify the physical properties of the wastes to increase the polarity and wettability thereof.

Method for cleaning the surfaces of a motor vehicle

The invention provides a composition for enhancing the biodegradation of biodegradable organic wastes comprising a combination of organic-waste consuming microorganisms and liposomes wherein the liposomes supply essential nutrients for bacterial growth while concomitantly increasing the polarity and wettability of the waste, thereby increasing their availability for enhanced bacterial interaction therewith and methods for the use thereof.

Composition for enhancing the biodegradation of biodegradable organic

Phorbine derivatives having high potency and light absorptivity in the 650 to 780 nanometer range are useful in cancer diagnosis and therapy, especially photodynamic therapy.

Phorbine derivatives and their use in the diagnosis and therapy of cancer

Method for enhancing the biodegradation of biodegradable organic wastes

The present invention provides a method for cleaning industrial and domestic surfaces and articles, as herein defined, which are contaminated with organic or lipophilic wastes, comprising applying liposomes thereto, which liposomes modify the physical properties of said wastes to increase the polarity and wettability thereof.

Method for cleaning industrial and domestic articles and surfaces

The invention provides a method for treating oil spills on water comprising applying liposomes to a body of water to form a monomolecular layer of phospholipid molecules on the water surface which phosopholipid molecules break up a continuous layer of oil into oil droplets each of which is surrounded by a monomolecular layer of phospholipids.

Method for treating oil spills on water

A method of recovering a petroleum from an underground source thereof comprising injecting into said underground source a petroleum displacement agent comprising a fluid and a modified liposome, said liposome being present in an amount sufficient to lower the interfacial tension between said fluid and said petroleum to below about 10 millidynes and the displacement agent.

Growing community of inventors

Jerusalem, Israel

Shimon Gatt