Amgen Inc.

Ambit Biosciences Corporation

Shimin Xu

Ning Xi

Andrew Stewart Tasker

Tae-Seong Kim

Celia Dominguez

Joseph L Kim

Julie Germain

Michael G Kelly

Vinod Francis Patel

Mark Henry Norman

Shon Booker

Liping H Pettus

Christopher Harold Fotsch

Qi Huang

Guoqing Paul Chen

Michael D Croghan

Daniel Elbaum

Chester Chenguang Yuan

Jean-Christophe P Harmange

Jean E Bemis

Leon M Smith, Ii

Thomas Stephen Coulter

Jeffrey A Adams

Chiara Ghiron

Michael K Handley

Lucian V Di Pietro

Xiaohu Ouyang

Gang Liu

Martin W Rowbottom

Qingyian Liu

Yuan Cheng

Guolin Cai

Ryan Paul Wurz

Mark W Holladay

Lucian V DiPietro

Steven F Bellon

Markian Myroslaw Stec

Nianhe Han

Michael J Hadd

Gregory J Habgood

Philip Miller

Matthew W Martin

Craig E Masse

David Craig McGowan

Matthew M Weiss

Brian Lewis Hodous

Longbin Liu

Dawei Zhang

Nuria A Tamayo

Vu Van Ma

Xianghong Wang

Daniel La

Russell Graceffa

Joseph J Nunes

Elizabeth M Doherty

Randall W Hungate

Stephanie Geuns-Meyer

Vassil I Ognyanov

Stuart C Chaffee

Deborah Choquette

Ning Chen

Brian K Albrecht

Nobuko Nishimura

Anthony B Reed

Robert Michael Rzasa

Ryan D White

Victor J Cee

Aaron C Siegmund

James Richard Falsey

Aiwen Li

Erin F DiMauro

Kelvin K C Sham

Yunxin Y Bo

Alexander S Kiselyov

Michael D Hocker

John F Kincaid

Michele Potashman

John Laird Buchanan

Vijay Keshav Gore

Chenera Balan

George Borg

Douglas A Whittington

William H Buckner

Yi-xin Qian

Adrian Leonard Smith

Paul A Tempest

Philip R Olivieri

Nick A Paras

Bradley J Herberich

Noel D'Angelo

David Bauer

Holly L Deak

Matthew Lee

Guo-Qiang Cao

Partha P Chakrabarti

Benny C Askew, Jr

Elizabeth Rainbeau

Premilla Arasasingham

David J Semin

Partha Chakrabarti

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFR&#x3b2; kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Heterocyclic compounds and methods of use thereof

Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

Substituted alkylamine derivatives and methods of use

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, A, B, R, R, R, R, Rand Z are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof

The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula I wherein A, A, A, A, A, A, Rand Rare defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula I, use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Triazole fused heteroaryl compounds and methods of use thereof

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Compounds and methods of use

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of p38 kinase mediated diseases and related inflammatory conditions. The compounds have a general Formula II wherein L, L, R, R, R, R, R, R, R, Rand p are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Phthalazine compounds and methods of use

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions. The compounds have a general Formula I wherein A, A, A, A, A, R, Rand Rare defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of inflammatory diseases including rheumatoid arthritis, psoriasis and other disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Pyrazolo-pyridinone derivatives and methods of use

Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Vanilloid receptor ligands and their use in treatments

Substituted heterocycles and methods of use

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A, A, A, A, B, R, R, R, Rand Rare defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Pyrazolo-pyridinone compounds and methods of use thereof

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein B, R, R, R, Rand Rare d.efined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

Growing community of inventors

San Diego, CA, United States of America

Shimin Xu