Bharat Serums and Vaccines Limited

Other

Shilpa Sudhakar Kocharekar

Sangeeta Hanurmesh Rivankar

Srikanth Annappa Pai

Sterile pharmaceutical stable autoclaved clear aqueous compositions of propofol (2,6-Diisopropyl phenol) suitable for parenteral administration are described. The compositions essentially consist of a complex of propofol with 2-hydroxypropyl-&#x3b2;-cyclodextrin in a weight ratio of 1:30&#x2013;1:60. This complex of propofol with 2-hydroxypropyl-&#x3b2;-cyclodextrin produces a clear aqueous composition that is stable to autoclaving. The composition is effective as an anaesthetic agent. The process of making these synergistic compositions has been described.

Clear aqueous composition comprising propofol and hydroxypropyl-beta-cyclodextrin

Parenteral compositions of oil-coated-Amphotericin B in structured-emulsion form, having LD50 of at least 400 mg/kg in mice and process for making the same have been described. The process essentially requires dispersing Amphotericin B in oily vehicle and dispersing emulsifier in the aqueous phase. The process of present invention is simple, cost effective and gives a stable product suitable for parenteral administration. Amphotericin B emulsion compositions prepared by the process of the present invention may be administered to human beings and animals for the treatment of fungal infections, with substantially equivalent or greater efficacy and low drug toxicity as compared to the conventional composition containing Amphotericin B and sodium desoxycholate.

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Maharashtra, India

Shilpa Sudhakar Kocharekar