University of Oklahoma

Shikha Srivastava

Robert H Cichewicz

Lin Du

Saikat Haldar

Allison O Mattes

Jianlan You

Cyclic depsipeptide-class molecules, referred to herein as persephacins (including analogs thereof), having similarities to aureobasidin A, are described. The persephacins have antimicrobial activity, such as antifungal activity against a diverse range of clinically-relevant fungal pathogens, antiprotozoan parasite activity, and antibacterial activity, and can be used for example in treatments of difficult-to-treat ocular fungal infections at lower concentrations than natamycin. The active compounds may be combined with a secondary compound in a composition.

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Norman, OK, United States of America

Shikha Srivastava