Council of Scientific and Industrial Research

Shikha Gupta

Suman Preet Singh Khanuja

Madan Mohan Gupta

Dharmendra Saikia

Ram Kishor Verma

Anil Kumar Gupta

Santosh Kumar Srivastava

Anirban Pal

Chandeshwar Nath

Subhash Chandra Singh

Janardan Singh

Vinay Kumar Khanna

Ashok Kumar Agrawal

Dnyaneshwar Umrao Bawankule

Anupam Maurya

The present invention relates to bioactive extracts its fractions and isolation of compound from. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D, Cholinergic (muscarinic) and Serotonergic (5HT) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and &#x3b1;-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions ofand in the isolated compounds &#x3b1;-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 

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Shikha Gupta