University of Tennessee Research Foundation

Other

Shijia Yan

Stephen C Johnson

David C Baker

Samuel F Victory

Ming Lou

Jianmin Mao

Anand Mayasundari

Prashant P Deshtande

Frank Tagliaferri

The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same

The invention relates to a new class of compounds herein identified generally as &ldquo;sultams&rdquo;, which may be represented by the following formula V, in FIG. 1, in which numbering of the atoms is started with the sulfur atom of the isothiazole. Two of the rings (rings A and C) are aromatic, and the third is a heterocyclic ring (ring B), a cyclic sulfonamide. Of particular importance are the enantiomerically pure sultams since they are especially potent HIV-1 inhibitors.

Methods of synthesizing sultams and anti-viral compositions

A method of synthesis of the four optically active stereoisomers of calanolide A and B which produces the compounds in high yields and in a high degree of purity.

Synthesis of optically active calanolides A and B and enantiomers and

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Birmingham, AL, United States of America

Shijia Yan