Industrial Technology Research Institute

Shih-Ta Chen

Pei-Shin Jiang

Ping-Fu Cheng

Chih-Peng Liu

Ming-Cheng Wei

Tseng-Huang Liu

Maggie Lu

Po-Yen Lin

Ya-Chin Lo

Shuen-Hsiang Chou

Hsiang-Wen Tseng

Ya-Ling Chiu

Kang-Li Wang

A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.

Nucleic acid-drug complex and use thereof

Disclosed is an intralymphatic delivery method for treating lymphatic cancer using hyaluronan nanoparticles. These nanoparticles include a hyaluronic acid derivative and a platinum compound. The hyaluronan derivative includes hyaluronic acid, modified histidine and optionally one or more of a polymer or a C-Calkyl. The hyaluronic acid derivative may include linking group(s) that connect the polymer or the C-Calkyl to the hyaluronic acid. The platinum compound includes dichloro(1,2-diaminocyclohexane) platinum (DACHPt), cisplatin and oxaliplatin. This intralymphatic delivery method offers significant advantages for the use of platinum medicines in treating lymphatic cancer.

Intralymphatic delivery of hyaluronan nanoparticle for cancer metastasis

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Taipei, Taiwan

Shih-Ta Chen