National Taiwan University

Taipei Medical University

Industrial Technology Research Institute

National Health Research Institutes

Shih-Lan Hsu

Ko-Jiunn Liu

Neng-Yao Shih

Yuan-Soon Ho

Sy-Jye Leu

Yi-Yuan Yang

I-Jen Huang

Chi-Hsin Lee

Wen-Shyang Hsieh

Hsueh-Hsia Wu

Shih-Yi Huang

Amily F Jou

Yen-Chuan Ou

Shian-Shiang Wang

Ja-An A Ho

Itamar Willner

Tzu-Ling Tseng

Chi-Ying Huang

Hui-Chu Hsieh

Yueh-Lun Lee

Yung-Luen Shih

Li-Jen Su

Ching-Yu Lin

The present invention provides a method for detecting a target nucleic acid that comprises a step of providing a sample; contacting the sample with a polynucleotide probe comprising a first sequence and a second sequence complementary to the target nucleic acid; and adding a nuclease for cleaving the second sequence of the polynucleotide probe. The present invention further provides a polynucleotide probe for detecting a target nucleic acid that comprises a first sequence and a second sequence complementary to the target nucleic acid. Moreover, the present invention provides a kit for detecting a target nucleic acid.

Polynucleotide probe, method for detecting a target nucleic acid by using the same and kit comprising the same

Kit comprising a polynucleotide probe for detecting a target nucleic acid

The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.

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The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.

Biomarkers for liver fibrotic injury

The present invention provides a method for the treatment and/or prevention of bacterial infection caused byand other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused byfamily in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused byfamily in central nervous system and/or peripheral blood circulation in a mammal.

Growing community of inventors

Taipei, Taiwan

Shih-Lan Hsu