National Health Research Institutes

Shih-Hsun Cheng

Chung-Shi Yang

Yeu-Kuang Hwu

Leu-Wei Lo

Jen-Kun Chen

Chia-Hung Lee

Wei-Neng Liao

Fong-Sian Lin

A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Auions; c) suspending the amine-modified silica particle in the solution comprising Auions; d) allowing the Auions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Auions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).

Solid phase gold nanoparticle synthesis

Growing community of inventors

Kaohsiung, Taiwan

Shih-Hsun Cheng