Ye Siang Enterprise Co., Ltd.

Development Center for Biotechnology

Taivex Therapeutics Corporation

Development Center of Biotechnology

Academia Sinica

Tunghai University

Shih-Hsien Chuang

Shih-Chieh Chuang

Wei-Kuo Kong

Ting-Fang Yu

Jiann-Jyh Huang

Win-Yin Wei

Yi-Jen Chen

Johnson Lau

Ying-Shuan Eda Lee

Yu-Ling Huang

Shih-Chong Tsai

Wei-Ting Sun

Chun-Liang Lai

Chao-Pin Lee

Wun-Huei Lin

Chun-Chung Lee

An-Suei Yang

Meng-Hsin Chen

Chung-Ming Yu

Hong-Sen Chen

Ching-Hui Chen

Chao-Yang Huang

Hwei-Jiung Wang

Yi-Kai Chiu

Hung-Ju Hsu

Paonien Chen

Cheng-Chou Yu

Chia-Cheng Wu

Chuan-Lung Hsu

Jia-Ming Chang

Shin-Chen Hou

Wei-Ying Kuo

Yueh-Liang Tsou

Chao-Cheng Chiang

Wei-Ting Chao

Tsung-Hui Li

Yu-Chin Nieh

Lien-Hsiang Chang

Ching-Yao Chen

Meng-Sheng Lee

Chiawei Liu

Shu Fu Lin

Yu-Hsiang Lin

Ru-Wen Wang

Sheng-Chuan Yang

Hui-Jan Hsu

Ying-Shuan Lailee

Gas phase filter

The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof

Cover for a fluid filter

A filtering module includes at least one reinforced aluminum side plate and at least one filtering mesh. The reinforced aluminum side plate surrounds to form a rectangular frame. The reinforced aluminum side plate includes a top plate, a connecting plate, a base plate and a positioning plate. The connecting plate is connected between the top plate and the base plate. The base plate and the top plate are substantially parallel with each other. The base plate has a treated surface away from the top plate and configured to abut against a fan filtering unit. The top plate has a supporting surface away from the base plate. The positioning plate is disposed perpendicularly on the supporting plate and aligns with the connecting plate. The filtering mesh is at least partially supported on the supporting surface and at least partially abuts against the positioning plate.

Filtering module

An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.

Antibody-drug conjugates and uses thereof

A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein-payload conjugates, as well as the conjugates produced thereby.

Processes for preparing glycoprotein-drug conjugates

Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as chemotherapeutic agents for neoplastic diseases.

Modulators of HEC1 activity and methods therefor

An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab&#x2212;(L&#x2212;D), wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

Antibody-drug conjugates containing anti-Globo H antibodies and uses thereof

Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.

High-throughput screening of functional antibody fragments, immunoconjugate comprising the same, and adaptor-drug conjugate for screening

Growing community of inventors

Taipei, Taiwan

Shih-Hsien Chuang