Biosensors International Group, Ltd.

Manli International Ltd.

Peregrine Ophthalmic Pte Ltd.

Duning Incorporated

Shih-Horng Su

Douglas R Savage

Ronald E Betts

John E Shulze

Sepehr Fariabi

Debashis Dutta

Ting-Bin Yu

Fuh-Sheng Chen

Tina Howden

Minh Nguyen

A method for reducing a subcutaneous fat deposit or a visceral fat deposit in vivo by contacting the fat deposit with a composition of latanoprost encapsulated in a liposome formed solely of egg phosphatidylcholine (EggPC) or palmitoyloleoyl phosphatidylcholine (POPC). Also disclosed are methods for treating steatoblepharon, proptosis, and obstructive sleep apnea associated with excess upper airway fat by injecting into the eyelid, intraconal space, and upper airway fat deposit, respectively, the composition of latanoprost encapsulated in an EggPC or POPC liposome.

Methods and compositions for reducing adipocyte numbers

An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 &#x3bc;in (0.5 &#x3bc;m) and a surface roughness range of between about 300-700 &#x3bc;in (7.5-17.5 &#x3bc;m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.

Drug delivery endovascular stent and method of use

Novel encapsulated umirolimus and umirolimus polymer conjugate formulations having enhanced permeability and retention at tumor sites. Also provided are methods for treating cancer by administering the umirolimus formulations.

Use of umirolimus and its derivatives for treating cancer

An expandable, bioabsorbable stent having a coiled-coil configuration is described. The stent further comprises regions of variable pitch that allow for variation in either rigidity, or variability diameter within sub-regions along the length of the deployed stent. By varying the diameter allows the stent to extend into regions such as branched vessels, or into the neck of aneurysms. In some embodiments, the stent comprises longitudinal support fibers that run substantially the length of the deployed stent to provide additional strength. In addition, the stent may also comprise regional support fibers that run less than the length of the stent, and which provide increased regional strength while permitting flexibility of the stent. The stent further comprises micro-tubes that are configured to be visible using medical imaging techniques. The stent can be manufactured from materials that are bioabsorbable and/or include the ability to release pharmacologically active substances over time.

Coil bioabsorbable stents

A bioabsorbable, expandable coil bifurcation stent having a first, second, and third segment, in which the second and third segments are extensions of a coiled fiber in the first segment. Also disclosed is a three-segment expandable coil bifurcation stent in which the second and third segments extend from supporting fibers in the first segment. Further disclosed is an expandable bifurcation stent in which supporting fibers in the first segment also support the second and third segments. The three segments are independently adjustable to fit varied geometries.

Coil bioabsorbable bifurcation stent

Devices and methods for controlling the flaking of coating fragments from medical implants and improving the delivery of therapeutic agents from such coatings are described.

Surface textured implants

Methods for producing drug-containing bioabsorbable fibers. Also disclosed are methods for treating diseases using a bioabsorbable drug delivery device.

Drug-containing bioabsorbable fibers and implants

A biodegradable polymer stent with radiopacity and a method of making and using a stent with enhanced mechanical strength and/or controlled degradation for use in a bodily lumen is described.

Temporal intraluminal stent, methods of making and using

A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.

Growing community of inventors

Irvine, CA, United States of America

Shih-Horng Su