Brown University

Shih H Chu

Paul Calabresi

Mahmoud H El Kouni

Fardos N Naguib

Sungman Cha

Ming Y Chu

Bai C Pan

Yung C Cheng

Novel 6-pyridyl substituted pyrimidine derivatives are disclosed for use as antiviral agents, particularly for the treatment of retroviral infections such as HIV infections and related disorders, as well as for use in anti-cancer therapies to improve the efficacy of anti-cancer therapeutics. These compounds and their pharmacologically acceptable salts operate to disrupt viral replication an exhibit lower cell toxicity, thereby providing more efficient agents for use alone or in conjunction with other chemical or biological agents to provide prolonged antiviral therapy. In addition, the compounds can be used to increase the efficacy of anti-cancer therapeutics including 5-fluropyrimidines such as 5-fluorouracil, thereby reducing the dosage requirement of the therapeutic in anti-cancer therapies so as to decrease toxic effects to the host.

6-pyridyl substituted pyrimidine derivatives

A compound of the Formula (I): ##STR1## where X is a benzyl group or a benzyloxybenzyl group and pharmaceutical preparations containing the same.

Hydroxymethyl derivatives of 5-benzylacyclouridine and

Growing community of inventors

Barrington, RI, United States of America

Shih H Chu