National Yang Ming Chiao Tung University

Merck Patent Gmbh

Shih-Chieh Hung

Harald Hirschmann

Alexander Hahn

Minghui Yang

Sven Christian Laut

Kuang-Ting Chou

Chi-Shun Huang

Philipp Wucher

Hee-Kyu Lee

A liquid-crystal (LC) material having negative dielectric anisotropy and the use thereof for optical, electro-optical and electronic purposes, such as for example in LC displays, in particular energy saving displays based on the ECB, IPS or FFS effect, where the liquid crystal medium contains one or more compounds of formula I and one or more compounds compounds of formulae IIA, IIB, IIC and IID

Liquid-crystal medium

The present invention relates to a use of hypoxia-cultured mesenchymal stem cells (MSCs) for manufacture of a cell graft for treating a musculoskeletal disorder, particularly osteoarthritis.

Use of mesenchymal stem cells in treating osteoarthritis

A method and a pharmaceutical composition for treating an atherosclerotic lesion are provided, including administering a subject in need thereof a therapeutically effective amount of a composition comprising hypoxia-cultured MSCs obtained by culturing auto- or allo-MSCs under low oxygen conditions.

Hypoxia-cultured mesenchymal stem cells for treating atherosclerotic lesions

The present invention relates to a novel method for expanding mesenchymal stem cells (MSCs) in low-density and hypoxic condition as compared to normal air conditions traditionally used in cell culture. The present method provides rapid and efficient expansion of human MSCs without losing cellular proliferation and stem cell properties, including increase in proliferation, decrease in senescence, and increase in differentiation potential both in vitro and in vivo. The expanded MSCs by the present method may maintain normal karyotyping, and will not form tumor when transplanted into mammal.

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Taipei, Taiwan

Shih-Chieh Hung