The Chinese University of Hong Kong

Massachusetts Institute of Technology

Lawrence Livermore National Security, LLC

Tissuevision, Inc.

The General Hospital Corporation

Carnegie Mellon University

Shih-Chi Chen

Martin L Culpepper

Dapeng Zhang

Sourabh Kumar Saha

Chenglin Li

Chenglin Gu

Yina Chang

Robert Matthew Panas

Ni Zhao

Ji Wang

Qiang Geng

Jiyi Cheng

Dien Wang

Pengfei Chen

Xi Zhou

Jialong Chen

Xiaogang Wang

Hongsheng Li

Aleksandra Klimas

Yongxin Zhao

Xinlei Fu

Yunlong Meng

Dihan Chen

Fei Han

Ningqi Luo

Jun Jiang

Yam Yeung

Chenyang Wen

Fu Feng

Wang Chen

Songyun Gu

Yan Huang

Huihua Xu

Hiu Hung Lee

Zihao Zhang

Xiangyu Fan

Erxuan Zhao

XiangBo Liu

The present disclosure relates to a method for performing an additive manufacturing operation to form a structure by processing a photopolymer resist material. A laser beam is directed at a tunable mask. At least one emergent beam is collected from a plurality of emergent beams emerging from the tunable mask. The at least one emergent beam is collimated to create a collimated beam. Each emergent beam from the tunable mask has a plurality of beam lets of varying or identical intensity, and each beam let emerges from a unique subsection or region of the tunable mask. The collimated beam is focused into a laser beam which is projected as an image plane onto or within the photopolymer resist material, such that the same optical path length is created between the tunable mask and the focused image plane for all optical frequencies of the focused laser beam. The focused laser beam illuminates a select pattern of subsections on the tunable mask for a finite duration of time to cause simultaneous polymerization of select portions of the photopolymer resist material corresponding to the select pattern.

System and method for submicron additive manufacturing

The disclosure relates to a method or a platform for hydrogel-based 3D fabrication, wherein the hydrogel is patterned with a programmable femtosecond light sheet with a power density of 0.1 to 100 TW/cm.

3D nanofabrication based on hydrogel scaffolds

A microtome comprises a support assembly; an actuator, mounted to the support assembly; a pair of oscillating flexure assemblies, held by the support assembly and each of which being located on one side of the actuator and oscillated by the actuator; and a blade assembly, mounted to each of the oscillating flexure assemblies so as to move in a direction same as the oscillating flexure assemblies.

Microtome and method for controlling and manufacturing the same

In some embodiments, a control system, a control method and a storage medium are provided. In the method, first motion information of a machine acquired by a first sensor is received; the first motion information is inputted into a deep learning model to obtain a model output, the deep learning model comprising a convolutional neural network (CNN) and a long short-term memory (LSTM); the deep learning model is trained using the first motion information and second motion information acquired by a second sensor; the first sensor and the second sensor having different ways of detecting information and processing the detected information. The model output is used to control the machine.

Control system, control method and computer storage medium

An apparatus is disclosed for performing an additive manufacturing operation to form a structure by processing a photopolymer resist material. The apparatus may incorporate a laser for generating a laser beam, and a tunable mask for receiving the laser beam which has an optically dispersive element. The mask splits the laser beam into a plurality of emergent beams each having a subplurality of beamlets of varying or identical intensity, with each beamlet emerging from a unique subsection of illuminated regions of the mask. A collimator collimates at least one of the emergent beams to form a collimated beam. One or more focusing elements focuses the collimated beam into a focused beam which is projected as a focused image plane on or within the resist material. The focused beam simultaneously illuminates a layer of the resist material to process an entire layer in a parallel fashion.

System and method for sub micron additive manufacturing

A liquid encapsulation device for embedding sensor is provided. The liquid encapsulation device comprises a substrate having an upper surface with a central concave portion; at least one protection layer sealed on the upper surface of the substrate; and at least one sensor fixed on the protection layer. Wherein, the central concave portion is filled with liquid and the sensor is arranged above the central concave portion.

Liquid encapsulation device and method for fabricating the same

A laser-based manufacturing system is disclosed for fabricating non-planar three-dimensional layers. The system may have a laser for producing a laser beam with a plurality of optical wavelengths. An optically dispersive element may be used for receiving the laser beam and splitting the beam into a plurality of distinct beam components, wherein each beam component has spatially separated optical spectral components. A phase mask may be used which is configured to receive at least one of the beam components emerging from the dispersive element and to create a modified beam. One or more focusing elements may then be used to receive the modified beam emerging from the phase mask and to focus the modified beam into a non-planar light sheet for use in fabricating a part.

System and method for curved light sheet projection during two-photon polymerization

The present disclosure discloses a method, a data acquisition and image processing system and a non-transitory machine-readable medium for obtaining a super-resolved image of an object. The method comprises: obtaining a plurality of structured images of the object by structured light; determining, from the structured images, modulation information of each structured light that comprises spatial frequency, phase shift and modulation factor; initializing a sample image of the object according the structured images and initializing structured pattern of each structured light by the corresponding modulation information; and restoring the image with improved resolution by adjusting the sample image and the structured pattern iteratively.

Method for data acquisition and image processing for reconstructing a super-resolved image

An apparatus and a method for laser beam shaping and scanning. The apparatus includes a digital micromirror device (DMD) including a plurality of micromirrors, configured to receive a first laser beam, adjust an axial position of a focal point of the first laser beam along a moving direction of the first laser beam by controlling a focal length of wavefront of a binary hologram applied to the DMD, and adjust a lateral position of the focal point on a plane perpendicular to the moving direction by controlling a tilted angle of a fringe pattern and a period of fringes of the binary hologram applied to the DMD, wherein the DMD simultaneously functions as programmable binary mask and a blazed grating.

Apparatus and method for laser beam shaping and scanning

A laser fabrication method and a laser fabrication system. The laser fabrication system includes an ultrafast laser source configured to output a laser beam; and a digital micromirror device (DMD), configured to receive, shape, and scan the laser beam, wherein more than one binary holograms are synthesized to form a scanning hologram applied to the DMD. The shaped laser beam, containing one or multiple focal points, leaving the DMD, are focused to the sample for fast laser fabrication.

Ultrafast laser fabrication method and system

Systems and methods for dicing a sample by a Bessel beam matrix are disclosed. The method for dicing a sample by a Bessel beam matrix may comprise generating a Bessel beam matrix including multiple Bessel beams arranged in a matrix form, according to a predetermined dicing layout of the sample; controlling a focus position of each Bessel beam in the generated Bessel beam matrix; and focusing simultaneously the Bessel beams of the Bessel beam matrix at the respective controlled focus positions within the sample for dicing.

Systems and methods for dicing samples using a bessel beam matrix

The present application discloses a microtome. The microtome includes: a blade cutting a soft material in a first direction, the first direction being a feeding direction of the soft material; a blade holder holding the blade; an actuator providing a vibration in a second direction along a cutting edge of the blade; and a frequency-tunable resonator driven by the actuator into vibration and fixedly connected to the blade holder to transfer the vibration to the blade holder and the blade, the resonator having a tunable resonant frequency in the second direction.

Microtome

A device and method are for shaping and scanning an ultrafast laser beam. The device includes a laser source configured to output a pulsed laser beam containing different frequency spectrum, a digital micromirror device (DMD) consisting of micromirrors, which are configured to receive the laser beam and shape the received laser beam with computer generated holograms, and a dispersion compensation unit, arranged before or after the DMD, which is configured to transfer the laser beam from the laser source to the DMD with a designated angular dispersion for neutralizing the first angular dispersion introduced by the DMD.

High-speed binary laser beam shaping and scanning

A laser manufacturing system capable of fabricating 3-D resolved 2-D patterns. The system includes a pulse laser source generating a laser beam; a reflectance mirror arranged in the propagation path of the laser to reflect the laser, the mirror being controllable to adjust an emergent angle of the laser; a deformable dispersion unit located in the laser receiving path from the reflectance mirror and having an array of micromirrors controllable in response to the adjusted emergent angle to form required laser patterns from the reflected laser, the laser patterns having spatially separated optical spectral components with multiple propagation angles; and one or more focusing optical components positioned in the propagation path of the separated optical spectral components produced by the deformable dispersion unit; the focusing components recombine the optical spectral components at fabrication targets with patterns defined by the deformable dispersion unit. The laser pulse duration is shortest on or inside the fabrication target along the laser propagation path.

Parallel laser manufacturing system and method

Methods and systems for axial-scanning a sample. The method may include generating a scanning beam along a transverse scanning direction across the sample; acquiring radial positions of the generated scanning beam along the transverse scanning direction; and determining, based on the radial positions of the generated scanning beam and desired focal lengths, a phase mask so that the scanning beam at different radial positions along the scanning direction is focused to different axial positions of the sample along an optical axis transverse to the scanning direction.

Growing community of inventors

Hong Kong, China

Shih-Chi Chen