Dalian University of Technology

Dalian Chromas Bioscience Co., Ltd.

Headwaters Technology Innovation, LLC

Other

Shenzhen Mindray Bio-medical Electronics Co., Ltd.

Zhuhai Ninestar Management Co., Ltd.

Dalian Firstar Information Materials Co., Ltd.

Ninestar Management Co., Ltd.

Dalian Institute

Shiguo Sun

Xiaojun Peng

Jiangli Fan

Jingyun Wang

Fengling Song

Bing Zhou

Gongquan Sun

Changkun Liu

Qin Xin

Tong Wu

Rong Zhang

Jianzhou Zhang

Shuihua Tang

Yanxia He

Zhigang Yang

Feng Wang

Bing Xu

Jianhui Shao

Shaolei Li

Jinhe Wu

Jianjun Du

Fan Jiangli

Licheng Liaoning

Zhi Long

Bingshuai Wang

Honglin Li

Licheng Wang

The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd, and its preparation method and use as well. Excitation and emission wavelengths of the probe compound are in visible light region. The probe compound is highly sensitive and displays good selectivity for Pdin near-neutral pH range. In detection of Pdin 0-10 ppb level, fluorescence is evidently enhanced, and Pdin the level as low as 5 nM can be detected. Fluorescence intensity is well linearly correlated to Pdconcentration. The probe compound can be used for detection of contaminating palladium and residual palladium in drug, soil, water sample and reactor.

Fluorescent probe compounds, preparation method and application thereof

A pentamethine cyanine fluorescent dye having the general formula I, a synthetic method and a use thereof are disclosed. In the general formula, X is CHO or CHCRR; Rand Rare independently selected from the group consisting of (CH)Rand et al.; Rand Rare independently selected from the group consisting of CN, COOH and COOR; R, Rand Rare independently selected from the group consisting of H, SORand COOR; Ris H or Calkyl; Ris H or CH; Ris N(RRRR); Ris Calkyl; R, R, R, Rand Rare independently selected from the group consisting of H, Calkyl, (CH)ORand (CHRCHO)R; Yis halogen anion or OTs; and n, m and p are integers of 0-18. The dye can be utilized to sensitively detect viscosity of micro-environment such as tissues and cells. 

Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof

The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), Xis H or COH; Xis OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when Xis OH, Xis H; when Xis phenyl group with 0-2 sulfonic acid substituents, Xis H or COH; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink. 

Carbonyl propyl sulfuryl anthrapyridone sulfonic acid compounds and their preparation methods and applications

A pentamethine cyanine fluorescent dye with N-substituting at &#x3b2;-position of conjugated chain is disclosed. The dye reacts with biosubstrate including protein, liposome and DNA, and shows excellent selectivity. It has good living cell membrane permeability and shows good selectivity in living cell staining In addition, the dye has good stability and low background fluorescence, and can be used together with other fluorescent dyes having consistent wavelengths for single-channel excitation and multi-channel detection. The dye can be used in the fields of protein labeling and detecting, fluorescence immunoassay and living cell selective imaging and the like.

Pentamethine cyanine fluorescent dye with N-substituting at &#x3b2;-position of conjugated chain

The disclosure provides fluorescence probe compounds of formula I, their preparation methods and applications. These compounds are useful in detecting mercury ions.

Fluorescent probe compounds, preparation method and use thereof

The invention is related to a weather-resistant dye and use thereof, which contains in molecules thereof not only chromophoric parent D, but also electron-accepting group Q which is linked with dye parent D through non-conjugated carbon link L to constitute D-L-Q dye molecule; the electron-accepting group Q has such a HOMO energy level that is lower than the HOMO energy level of the dye chromophoric parent D. The dye has sun-resistance and anti-ozone performances, which can be used as colorant in the ink, dope, lacquer, toner powder for laser printing, marker, paper, fabric, glass, porcelain or polymer.

Weather-resistant dye and use thereof

The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH), O, S or Se; m is an integer from 1 to 18, Rand Rare each independently chosen from H, Calkyl, OR, Calkyl-ORor halogen; Ris pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHRor N(R); Ris Calkyl, benzyl or (CH)R; Ris saturated and/or unsaturated, straight-chained and/or branched-chained Calkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; Ris a Calkyl; Ris H or a Calkyl; Yis an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc. 

Fluorescent dyes, methods of synthesis and applications thereof

The fuel cells include electrode membrane assemblies having a nanoparticle catalyst supported on carbon nanorings. The carbon nanorings are formed from one or more carbon layers that form a wall that defines a generally annular nanostructure having a hole. The length of the nanoring is less than or about equal to the outer diameter thereof. The nanorings exhibit high surface area, high porosity, high graphitization, and/or facilitate mass transfer and electron transfer in fuel cell reactions.

Fuel cells and fuel cell catalysts incorporating a nanoring support

Methods for manufacturing carbon nanostructures include 1) forming intermediate carbon nanostructures by polymerizing a carbon precursor in the presence of templating nanoparticles, 2) carbonizing the intermediate carbon nanostructures to form an intermediate composite nanostructure, and 3) removing the templating nanoparticles from the intermediate composite nanostructure to form carbon nanorings. The carbon nanorings manufactured using the foregoing steps have one or more carbon layers forming a wall that defines a generally annular nanostructure having a hole. The length of the nanoring is less than or about equal to the outer diameter thereof. The carbon nanostructures are well-suited for use as a fuel cell catalyst support. The carbon nanostructures exhibit high surface area, high porosity, high graphitization, and facilitate mass transfer and electron transfer in fuel cell reactions. Carbon nanorings manufactured according to the present invention can be used as a substitute for more expensive and likely more fragile carbon nanotubes.

Carbon nanorings manufactured from templating nanoparticles

The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R, R, R, R, Rand Yare as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof. 

Asymmetric cyanine fluorescent dyes

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Dalian, China

Shiguo Sun