Other

Taisho Pharmaceutical Co., Ltd.

Nihon Nohyaku Co., Ltd.

Shigeyuki Chaki

Atsuro Nakazato

Kazuyuki Tomisawa

Masanori Yoshida

Masashi Nagamine

Toshihito Kumagai

Taketoshi Okubo

Makoto Gotoh

Toshio Nakamura

Hiroshi Ohta

Dai Nozawa

Tomoko Tamita

Seiji Masuda

Toshiharu Shimazaki

Aya Fujino

Shuhei Kashiwa

Makoto Tatsuzuki

Kenji Yamamoto

Koichiro Harada

Hideo Tanaka

Takaaki Ishii

Kazunari Sakagami

Akito Yasuhara

Shigeru Okuyama

Izumi Aibe

Shin-ichi Ogawa

Shiho Hirota

Ryoko Dean

Kuniaki Kondoh

The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases. A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein or the like}.

Phenylpyrazole derivatives

An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: [wherein Rand R, which may be the same or different, each represent a hydroxyl group, a Calkoxy group, etc.; Rrepresents a Cacyl group, a Calkoxy-Cacyl group, etc.; and Rand R, which may be the same or different, each represent a hydrogen atom, a Calkyl group, etc.] or a pharmaceutically acceptable salt or hydrate thereof.

6-Fluorobicyclo[3.1.0]hexane derivatives

There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MCreceptor antagonist as an effective ingredient; and a piperazine derivative represented by Formula [1]:[wherein Aris a phenyl group, a substituted phenyl group, a naphthyl group or a substituted naphthyl group; Aris a naphthyl group, a substituted naphthyl group, a quinolyl group, a group represented by the formula:(wherein Ris a hydrogen atom or a halogen atom; and X&#x2014;Y is CH&#x2014;NH, CH&#x2014;O, CH&#x2014;S or N&#x2014;O) or a group represented by the formula:(wherein Ris a hydrogen atom, a hydroxyl group or a Calkoxy group); Ris a hydrogen atom, a Calkyl group, a Ccycloalkyl group, a Calkenyl group, a phenyl group, a 1-cyanoethyl group, a pyrimidin-2-yl group or an amidyl group; Rand Rare the same or different, and are each a hydrogen atom or a Calkyl group; A-B is N&#x2014;CH, CH&#x2014;CH, C(OH)&#x2014;CHor C&#x2550;CH; Tis a single bond, &#x2014;N(R)&#x2014; (wherein Ris a hydrogen atom or a Calkyl group), &#x2014;O&#x2014;, &#x2014;CH&#x2550;CH&#x2014; or &#x2014;C(&#x2550;O)&#x2014;; n is an integer of from 1 to 10 and when Tis a single bond, &#x2014;CH&#x2550;CH&#x2014; or &#x2014;C(&#x2550;O)&#x2014;, n is an integer of from 2 to 10 when Tis &#x2014;N(R)&#x2014; or &#x2014;O&#x2014;], or a pharmaceutically acceptable salt thereof.

Remedial agent for anxiety neurosis or depression and piperazine derivative

Arylpiperidine derivatives and use thereof

Heterocycle substituted aryloxyaniline derivatives and their use as MDR ligands

1,2-dihydro-2-oxoquinoline derivatives

An aryloxyaniline derivative represented by the formula:

Aryloxyaniline derivatives

A 1,2-dihydro-2-oxoquinoline derivative represented by the formula:

1,2-Dihydro-2-oxoquinoline derivatives

An aromaheterocyclic derivative represented by the formula:

Heteroaromatic derivatives

A nitrogen-containing tetracyclic compound represented by the formula:

Nitrogen-containing tetracyclic compounds

A 4-tetrahydropyridylpyrimidine compound represented by formula (I):

4-Tetrahydropyridylpyrimidine derivatives

2-carbonylthiazole derivatives and use of the same

Growing community of inventors

Tokyo, Japan

Shigeyuki Chaki