Kyowa Hakko Kogyo Co., Ltd.

Shigeyoshi Yasumura

Tatsunari Nishi

Seiga Ito

Katsutoshi Sasaki

Moriyuki Sato

Seiga Itoh

A novel plasminogen activator which is identical in peptide sequence to naturally occurring human prourokinase except that the 155th amino acid counting from the N-terminal amino acid (serine)] is other than the 155th amino acid (proline) of naturally occurring human prourokinase, optionally with the addition of methionine at the N terminus.

Plasminogen activator

A polypeptide or glycosylated polypeptide with at least one new carbohydrate chain produced by means of recombinant DNA technique, which has protease resistance and thermal stability and is expected to have longer lifetime in blood than those of a naturally-occurring form.

Modified granulocyte-colony stimulating factor polypeptide with added

A novel plasminogen activator which is identical in peptide sequence to naturally occurring human prourokinase except that the 155th amino acid counting from the N-terminal amino acid (serine) is other than the 155th amino acid (proline) of naturally occurring human prourokinase, optionally with the addition of methionine at the N terminus.

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Tokyo, Japan

Shigeyoshi Yasumura