Ajinomoto Co., Ltd.

Shigeyoshi Miyashiro

Tsuyoshi Shiio

Takao Kida

Hiroshiro Shibai

Shigezo Udaka

Koichi Ishii

Toshihiko Ando

Yoshio Hirose

Kazuo Hirayama

Tetsuo Tanegawa

Takeyoshi Awao

Asao Murai

Masayoshi Kusatsu

Junji Nakamura

Eikou Shimizu

The present invention relates to a water-insoluble glucan purification method characterized in that a culture solution of a microbe that produces water-insoluble glucan or a microbial cell-containing solution comprising water-insoluble glucan as a component is treated with both an oxide of 0.175-3.5 wt.--wt. % and a hydroxide such that the pH value becomes 10-12.5. Since the present invention accomplishes all of the destruction of production microbe, the decolorization and the reduction of viscosity of a culture solution of a microbe that produces water-insoluble glucan or a microbe cell-containing solution comprising water-insoluble glucan as a component, the invention purifies water-insoluble glucan industrially at low costs and with a high efficiency.

Water-insoluble glucan purification method

By irradiating a polyene antibiotic having a cis-type polyene structure with long wavelength ultraviolet light, it is possible to prepare the corresponding antibiotic having a trans-type polyene structure in high yield in a simple manner. Such antibiotics having a trans-type polyene structure exhibit strong antimicrobial activities and are useful as drugs for humans or animals.

Process for producing a polyene antibiotic

This invention relates to an antitumor composition of anthracycline compounds bonded to hydrophilic polypeptides having a molecular weight between 10,000 and 15,000.

Anthracycline compounds bound to hydrophilic polypeptides

A streptothricin-group compound having the formula: ##STR1## in which R represents ##STR2## is disclosed along with methods for producing this compound and a microorganism useful in its production.

Streptothricin-group compounds

A high molecular weight peptide antibiotic designated as AN-7D which is effective as an agent.

High molecular weight antitumor antibiotic AN-7D

Microorganisms of the genus Aspergillus produce mucopolysaccharides having flocculating activity for protein.

Growing community of inventors

Yokohama, Japan

Shigeyoshi Miyashiro