Nagase Co., Ltd.

Nagase Chemicals Ltd.

Shigeya Saijo

Masafumi Moriwaki

Jun Matsumoto

Hiroyuki Nohira

Shunji Kamiyama

Ikuya Tanaka

Yasuo Chikusa

Yuji Yanagida

Taizo Fujimoto

Toshimasa Ohnishi

Kohichi Maruo

Keita Umetsu

Kazutoshi Toyoda

Iodopropargyl derivatives and antimicrobial agents comprising them as an

Provided is a process for separating (S)- or (R)-2-(3-benzoylphenyl)propionic acid from a mixture of (S)- and (R)-2-(3-benzoylphenyl)propionic acid, which comprises (1) reacting the mixture of (S)- and (R)-2-(3-benzoylphenyl)propionic acid with (S)- or (R)-3-methyl-2-phenylbutylamine in a suitable solvent to form a diastereomer salt of (S)-2-(3-benzoylphenyl)propionic acid with (S)-3-methyl-2-phenylbutylamine or a diastereomer salt of (R)-2-(3-benzoylphenyl)propionic acid with (R)-3-methyl-2-phenylbutylamine; (2) separating the diastereomer salt from the reaction mixture; and (3) liberating the separated diastereomer salt to give (S)- or (R)-2-(3-benzoylphenyl)propionic acid. According to the present process, it is possible to obtain optically active (S)- or (R)-2-(3-benzoylphenyl)propionic acid having 99% or more of high optical purity in a high yield. Thus, the present process is a practical and efficient process which can simplify purification steps and can be applied for an industrial production process.

Process for optically resolving 2-(3-benzoylphenyl) propionic acid

Growing community of inventors

Nishinomiya, Japan

Shigeya Saijo