Fujifilm Corporation

Fujifilm Toyama Chemical Co., Ltd.

Fuji Photo Film Company, Limited

Shigetomo Tsujihata

Shinichi Hashimoto

Yasuyuki Izumi

Toshiyuki Makuta

Masaaki Konno

Tetsuzo Kadomatsu

Masanobu Takashima

Ryoichi Nakano

Tsutomu Umebayashi

Shojiro Sano

Takehiko Sato

Kotaro Okada

Yoshinori Sakata

Norihide Shimohara

Hisato Nagase

Shinichiro Serizawa

Yutaka Maeno

Kousaku Yoshimura

Hisahiro Mori

Shirou Sonoke

Tsutomu Umebayasi

An object of the present invention is to provide a pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof at a high concentration, with a characteristic bitter taste masked, and a manufacturing method thereof. The present invention provides a pharmaceutical composition comprising fine granules having a core comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof, and a binder; and a polymer layer with which a surface of the core is coated, wherein the fine granules have a roundness of 0.8 or more and a content of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or the salt thereof in the fine granules is 30 to 90% by mass.

Pharmaceutical composition and method of manufacturing the same

An object of the present invention is to provide a solid pharmaceutical composition which suppresses the characteristic bitter taste of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and has a good storage stability of the-aforementioned compound or a salt thereof. The present invention provides a solid pharmaceutical composition comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof and a carboxylic acid whose solubility in water at 25&#xb0; C. is 50 g/100 g HO or less, wherein pH of a solution obtained when the solid pharmaceutical composition is dissolved or suspended in a 10 mmol/L KCl solution such that 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or the salt thereof is 1 mg/mL or 8.96 mg/mL is 4.8 or less.

Pharmaceutical composition

Provided are an injection preparation which includes: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent A which is selected from the group consisting of cysteine and a salt thereof, and of which the content is 0.001 mass % to 0.1 mass % with respect to the total mass of the aqueous composition, thioglycerol of which the content is 0.001 mass % to 0.1 mass % with respect to the total mass of the aqueous composition, and an aqueous solvent of which the content is greater than or equal to 50 mass % with respect to the total mass of the aqueous composition, and a container which seals the aqueous composition, in which the concentration of oxygen in gas within the container which seals the aqueous composition is less than or equal to 2.0 volume %, and a method for producing the injection preparation.

Injection preparation and method for producing the same

Provided are an injection preparation which include: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent which is selected from the group consisting of ascorbic acid, an ascorbic acid derivative, and salts thereof, and the content of which is 0.0001 mass % to 0.5 mass % with respect to the total mass of the aqueous composition in terms of ascorbic acid, and an aqueous solvent of greater than or equal to 50 mass % with respect to the total mass of the aqueous composition; and a container which encloses the aqueous composition, in which the concentration of oxygen in gas within the container which encloses the aqueous composition is less than or equal to 0.2 volume %, and a method for producing the injection preparation.

Injection preparation and method for producing same

An aqueous ophthalmic composition includes a carbonic anhydrase inhibitor; at least one cellulose derivative selected from the group consisting of hydroxypropylmethyl cellulose acetate succinate and carboxymethylethyl cellulose; and water.

Aqueous ophthalmic composition

An emulsion composition includes a compound having a diaminopyrimidine skeleton, at least one fatty acid component selected from the group consisting of a fatty acid having a total carbon number of 14 or more and a salt thereof, and an aqueous medium in an amount of 50% by mass or more with respect to the mass of the emulsion composition. The total amount of monohydric alcohol having a total carbon number of 3 or less and dihydric alcohol having a total carbon number of 3 or less is less than 10% by mass with respect to the mass of the emulsion composition. The emulsion composition has a pH of 6.5 or more.

Emulsion composition

A pharmaceutical composition including drug-containing nanoparticles having an average particle diameter of from 10 nm to 150 nm, the pharmaceutical composition being obtained by mixing water with a poorly water soluble drug-containing, water miscible solution that contains a poorly water soluble drug having a water solubility of 50 &#x3bc;g/mL or less, a water soluble copolymer having a repeating unit represented by the following Formula (1), and a water miscible miscible solvent, wherein in Formula (1), n:m is within a range of from 0.25:0.75 to 0.95:0.05, R represents an alkyl group which may have a substituent, Rand Reach independently represent a hydrogen atom or a methyl group, and Me represents a methyl group; and a preparation for oral administration, which includes the pharmaceutical composition. 

Pharmaceutical composition and preparation for oral administration

A polymerizable compound represented by the following formula (1): 

Polymerizable compound, polymer, ink composition, printed articles and inkjet recording method

Disclosed are an ink composition comprising at least a colorant (a) and a polymer (b) having a heterocyclic moiety forming a colorant, an image forming method including applying the ink composition to a recording medium by printing and curing the ink composition, and a printed article produced by curing the ink composition.

Ink composition, image forming method and printed article

The invention provides an ink-jet recording ink set including at least one first liquid A for at least forming an image and at least one second liquid B having a different composition from the composition of the first liquid A, wherein the first liquid A contains at least a polymer having a heterocyclic residue for forming a colorant, and a pigment, as well as an ink-jet recording method using the ink set.

Ink-jet recording ink set and ink-jet recording method

The present invention provides an inkjet-recording ink set including multiple kinds of liquid including at least first and second liquids, wherein the first liquid contains a metal compound dissolved therein, and at least one of the multiple kinds of liquid contains a polymerizable compound. The invention also provides an inkjet-recording ink including at least a high-boiling-point organic solvent and a metal compound. The multiple kinds of liquid contain substantially no water and no low-boiling-point organic solvent.

Inkjet-recording ink set, inkjet-recording ink and inkjet image-recording method

An ink set for ink jet recording, an ink for ink jet recording and an ink jet recording method capable of suppressing bleeding and the interference between discharged droplets to form high-quality images can be achieved by an ink set for ink jet recording, having plurality of liquids containing at least a first liquid and a second liquid, wherein the first liquid has an oil-soluble polymer dissolved therein, and at least one of a plurality of the liquids contains a polymerizable compound, as well as by an ink jet image recording method which uses the ink set and applying the first and second liquids simultaneously onto a recording medium, or first applying one of the liquids and then the other onto a recording medium such that the two liquids contact each other to form an image.

Ink set for ink jet recording, ink for ink jet recording, and ink jet image recording method

The present invention provides ink jet recording sheets comprising a colorant receiving layer on a substrate, the colorant receiving layer comprising fine particles, a water soluble resin, and a cationic resin including a unit represented by the following formula (1): 

Ink jet recording sheet

The present invention provides a recording medium including a recording layer on a substrate, wherein the recording layer includes a polymer that has a thioether bond, has a sulfur equivalent of no less than 1.2 meq/g, and has an inorganic/organic ratio (I/O value) represented in an organic-inorganic conceptional diagram of no less than 0.5. According to the invention, the recording medium may be an ink jet recording medium, in which the recording layer is an ink receiving layer.

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Kanagawa, Japan

Shigetomo Tsujihata