Otsuka Pharmaceutical Company, Limited

Shigeto Uchiyama

Tomomi Ueno

Seiichi Shimizu

Megumi Kumemura

Kyosuke Masaki

Toshimi Suzuki

Kiyoko Imaizumi

Yasuhiro Abiru

Masamichi Toba

Shuichi Sakamoto

Yoshikazu Isono

Rieko Endo

Reiko Ohta

Hisako Mori

Masahiro Oono

Hiroyuki Kimura

Ikutaro Sato

Takeshi Yamauchi

Kentaro Tadano

Masatoshi Mizuno

An equol-producing lactic acid bacteria-containing composition comprises, as an essential component thereof, a lactic acid bacterial strain belonging to the genushaving an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.

Equol-producing lactic acid bacteria-containing composition

An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.

Fermentation product containing equol-producing microorganism having maintained equol-producing ability, and method for producing same

An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.

Equol-containing fermentation product of soybean embryonic axis, and method for production thereof

The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genushaving an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.

This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.

Isoflavone-containing composition

Microbial method of making equol-containing composition and product made

The antioxidation food product of the present invention is produced by fermenting a food product containing bacteria having catalase activity, such as, in the presence of a manganese-containing natural material. The antioxidation food product has antioxidation activity in viva, including the digestive tract, by simultaneously expressing a superoxide dismutase-like activity and a catalase activity, and is effective for preventing disease caused by active oxygen.

Antioxidation food product, antioxidation preparation and antioxidation method

This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly woman for which no effective means of prevention or alleviation has heretofore been available.

Streptococcus and isoflavone-containing composition

The antioxidation food product of the present invention is produced by fermenting a food product containing bacteria having catalase activity, such as,, in the presence of a manganese-containing natural material. The antioxidation food product has antioxidation activity in vivo, including the digestive tract, by simultaneously expressing a superoxide dismutase-like activity and a catalase activity, and is effective for preventing diseases caused by active oxygen.

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Miyaki-gun, Japan

Shigeto Uchiyama