Kao Corporation

Shigeto Kayane

Takashi Imamura

Tomihiro Kurosaki

Yasuteru Eguchi

Manabu Tonomura

Hidetake Fujinaka

Masanobu Tanigaki

Takahisa Yamashiro

Satoshi Tsujita

Yoshitaka Yano

Akira Suzuki

Koji Maeda

Yoshiaki Fujikura

Yoshinori Murakami

Katsumi Kita

Kazuhiko Kato

Hiromoto Mizushima

Yukihiro Nakano

Atsushi Yamagishi

Akira Oshima

Takashi Kawai

Kenji Hara

Ryozo Nakai

Yoshinao Nagashima

Junji Nakamura

Masaru Sakata

Mitsuyoshi Kashiwagi

Katsuya Ueno

Hidenori Yoshida

Shinji Kiji

Morihide Itano

Mitsugu Morishita

Masakazu Murata

Yoshitaka Yanou

Keiko Masuki

Kazuhiko Katou

Provided is a solid preparation for oral application containing (a) gum tragacanth and (b) a polyphosphoric acid or salt thereof and constituted so that the polyphosphoric acid or salt thereof starts to dissolve firstly and the gum tragacanth starts to dissolve subsequently. The solid preparation for oral application according to the present invention has a high plaque formation inhibiting effect.

Solid preparation for oral application

The present invention relates to an oral care composition, which contains a compound represented by the formula (A): (wherein, R represents a substituted or unsubstituted, linear or branched alkyl group having from 6 to 18 carbon atoms, G represents a galactose residue, m stands for an integer of from 0 to 200, and n stands for an integer of from 1 to 30); and a coaggregation inhibitor of bacteria of the genusand cariogenic bacteria, which contains the compound as an effective ingredient. The composition for oral cavity according to the present invention inhibits coaggregation of bacteria of the genuswith cariogenic bacteria so that it has an excellent caries preventive effect.

Composition for oral cavity

Provided is a toothpaste composition providing a pleasant cooling sensation and has excellent storage stability. The toothpaste composition contains from 30 to 60 wt % of erythritol having an average particle size of 200 &#x3bc;m or less as Component (A), from 15 to 30 wt % of water as Component (B), and from 0.6 to 3 wt % of a binder as (C1).

Toothpaste composition

The present invention relates to a liquid composition for the oral cavity, which contains the following components (A), (B), (C) and (D): The present invention also pertains to a liquid composition for the oral cavity, which contains the following components (A), (B), (E) and (F): The liquid composition for the oral cavity according to the present invention is excellent in the adsorption of the bactericide to teeth and the like, barely causes unpleasant odor, and is excellent in stability.

Liquid compositions for the oral cavity

This invention relates to compositions for the oral cavity, each of which comprises (A) a pharmaceutically-active agent, which acts on the periodontium, or a microbicidal agent and (B) an exothermic ingredient or a water-soluble high-molecular substance, and has a water content not higher than 5 wt. %. They permit adsorption of a pharmaceutically-active agent or the like at a high rate on the oral mucosas and are excellent in the effects of preventing and/or treating paradental diseases.

Compositions for oral cavity

The present invention relates to a solid preparation for oral hygiene, which comprises (a) 15 to 90 wt. % of a bubbling component and (b) 0.001 to 10 wt. % of an orally-usable medicinal component at an (a):(b) ratio ranging from 10:1 to 1000:1. Use of the preparation brings about a drastic improvement in the drug efficacy and moreover, breath is freshened by bubbling.

Solid preparation for oral hygiene

Coating composition for teeth

A process for preparing glucose-1-phosphate from an .alpha.-glucan and orthophosphate using a phosphorylase immobilized onto an anion-exchange resin is disclosed. The anion-exchange resin used is a synthetic polymer resin into which an anion exchange group; a primary to quarternary ammonium group, a phosphonium group, or a sulfonium group, is introduced. This type of immobilized phosphorylase ensures (i) an effective utilization of phosphorylase, (ii) a higher reactivity of a higher absorbance of the phosphorylase to the resin, (iii) an excellent phosphorylase activity retention performance, and (iv) a higher physical strength of the resin.

Immobilized phosphorylase

A method of desensitizing hypersensitive dentin is disclosed. The method comprises treating teeth of patients suffering from hypersensitive dentin with a colloid produced by mixing (a) a salt of polyvalent metal and (b) a polyol phosphate and/or a water-soluble salt thereof. The colloid can constrict or occlude dentinal tubules in the tooth dentin, exhibiting a continuous effect on the desensitization of hypersensitive dentin owing to the very high absorptivity of the colloid to teeth. The colloid does not impair taste, and does not produce precipitate near the neutral region, enabling it to be used safely.

Method of desensitizing hypersensitive dentin

A colloidal solution comprises a fluoride(s) being difficultly soluble in water comprises colloidal particles of the fluoride having a particle size of 0.005 to 1 micron, said fluoride having a fluoride ion concentration of 1 to 10,000 ppm in the state of saturation.

Fluoride colloid and oral composition

A colloidal solution comprises a fluoride(s) being difficultiy soluble in water comprises colloidal particles of the fluoride having a particle size of 0.005 to 1 micron, said fluoride having a fluoride ion concentration of 1 to 10,000 ppm in the state of saturation.

Oral compositions containing colloidal fluoride

A preventive and therapeutic method for hypertension by dosing hexose phosphate calcium which produces an immediate effect without having any undesirable side-effects to control a rise in the blood pressure, and is efficacious also for various diseases of which onset can be ascribed to hypertension, such as myocardial infarction, cerebral apoplexy, cirrhosis of livers, billiary stasis, and others.

Preventive and therapeutic method for hypertension

A novel method for purifying a sugar phosphate or its salt, in which a sugar-containing mixture of a sugar phosphate or its salt and phosphoric acid or its salt is subjected to electrodialysis to remove the phosphoric acid or its salt from the mixture. According to this method, the phosphoric acid or its salt can be readily obtained in a reusable form. The method is thus quite advantageous in view of the economy.

Method for purifying sugar phosphates or their salts

Sugar phosphate of the following general formula (I): ##STR1## is prepared by reaction between a phosphoric monoester and a glycidyltriammonium salt. The sugar phosphate according to the invention has good moisture retention and good adsorptivity on hair, and can be used in shampoos, rinses and cosmetics.

Growing community of inventors

Tokyo, Japan

Shigeto Kayane