Other

Astellas Pharma Gmbh

Shigeru Yamazaki

Atsushi Maeda

Yuuki Takaishi

Takao Mizumoto

Naoki Itou

Tatsuki Shinoda

Shigeru Suzuki

Akira Ito

Hiroshi Sugiura

Takashi Yokota

Kunihiko Ikeda

Akira Shimura

Yutaka Kodama

Masaichi Niro

Satoru Tomita

The present invention relates to a composition comprising sustained-release fine particles, characterized in that it contains sustained-release fine particles that can be used in quick-disintegrating tablets in the buccal cavity, one or more fillers selected from the group consisting of sugars or sugar alcohols, and one or more binders for quick-disintegrating tablets in the buccal cavity selected from the group consisting of sugars of high moldability and water-soluble polymer substances, and in that the sustained-release fine particles are granulated with filler and binder for quick-disintegrating tablets in the buccal cavity, and a manufacturing method thereof.

Composition comprises sustained-release fine particles and manufacturing method thereof

The present invention is to provide a stabilized pharmaceutical composition for oral use containing 1-ethyl methylester 4-&lsqb;&lsqb;3-&lsqb;p-(carboxyamidino)phenyl&rsqb;-2-oxo-5-oxazolidinyl&rsqb;methyl&rsqb;-1-piperazineacetate or a pharmaceutically acceptable salt thereof having an antagonistic action to GPIIb/IIIa receptor and an oily base. The present invention is to further provide a method for the manufacture of a stabilized pharmaceutical composition for oral use by compounding 1-ethyl methylester 4-&lsqb;&lsqb;3-&lsqb;p-(carboxyamidino)phenyl&rsqb;-2-oxo-5-oxazolidinyl&rsqb;methyl&rsqb;-1-piperazineacetate or a pharmaceutically acceptable salt thereof with an oily base. The present invention is to furthermore provide a method for the stabilization of a pharmaceutical composition by compounding 1-ethyl methylester 4-&lsqb;&lsqb;3-&lsqb;p-(carboxyamidino)phenyl&rsqb;-2-oxo-5-oxazolidinyl&rsqb;-methyl&rsqb;-1-piperazineacetate or a pharmaceutically acceptable salt thereof with an oily base.

Pharmaceutical composition for oral use

A printer has a record unit including a record in the form of an endless belt which moves in one direction, a charger for charging the record, an exposure unit for forming an electrostatic latent image on the charged record, a developing unit for converting the latent image into a visual image, a sheet feeder for feeding a record sheet from a stack, as separated one by one, and feeding it into close contact with the record which carries the visual image, a transfer unit for transferring the visual image from the record onto the record sheet, a fixing unit for fixing the transferred visual image on the record sheet, and a delivery unit of delivering the fixed record sheet out of the printer. As a characteristic of the invention, the record unit and the developer unit are detachably mounted together and capable of being slid out of the printer for servicing. The other elements of the printer are disposed around the record unit in a generally U-shaped configuration, so that the record/developer unit can be slid into or out of the hollow portion defined by the U-shaped configuration.

Printer

Growing community of inventors

Shizuoka, Japan

Shigeru Yamazaki