Eisai Company, Limited

Shigeru Sakashita

Yasuo Miyake

Takayuki Ohwaki

Takeshi Nakagawa

Masanori Kayano

Masahiro Kawahara

Masayoshi Kasai

Shigeru Aoki

Keizo Uesugi

Aishin Shinoda

A multi-layered granule comprises an inner, slow-releasing layer, an outer, rapid-releasing layer and an intermediate layer provided between said slow-releasing layer and said rapid-releasing layer which intermediate layer comprises a hardened oil and hydroxypropyl cellulose or methyl cellulose.

Multi-layer granule

An inclusion compound composed of tripamide and cyclodextrin markedly improves the solubility of tripamide which is effective for treatment of essential hypertension.

Tripamide and cyclodextrin inclusion compound

This invention provides a process for sealing a body and a cap of a capsule which comprises successively dipping a gelatin hard capsule containing drugs one by one in a mixed solvent of water and ethanol whose volume ratio to water is 50-55%, thereafter taking said capsule out of this solvent and drying each capsule separately.

Process for sealing body and cap of gelatin hard capsule and apparatus

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Gifu, Japan

Shigeru Sakashita