Nof Corporation

Nippon Oil Fats Co., Ltd.

Shigeru Kitano

Tsuyoshi Miyazaki

Tohru Yasukohchi

Yoshishige Murata

Kouzoh Sanchika

Akinori Suginaka

Yoshihito Kadoma

Mitsuhiro Nishida

Akio Hayashi

Masayuki Yokoyama

Kazunori Kataoka

Yasuhisa Sakurai

Kazuhiro Kubo

Toshihiko Ohta

Atsuhiko Ogura

Shinji Tanaka

Kazuo Matsuyama

Yoshiyuki Koyama

Kenichiro Nakamoto

Yoshikazu Nakashima

Daijiro Shiino

Kazunori Waki

Motoharu Iwatsuru

Kazuo Maruyama

Hiroshi Suzuki

Chika Ito

Yoshikazu 20-201 Azanakamichi Nakashima

A method for producing a biodegradable polyoxyalkylene derivative, includes: reacting a biodegradable polyoxyalkylene compound represented by the formula (1) as defined herein with a compound represented by one of the formulae (I) to (IV) as defined herein in a presence of an alkaline solid salt, the biodegradable polyoxyalkylene derivative being represented by the formula (2) as defined herein.

Method for producing biodegradable polyoxyalkylene derivative

A novel A-B-Apolymer having a number average molecular weight of 10000 to 100000 is provided that has excellent bioabsorbability so as to disappear in a predetermined period of time even when embedded in a large amount in the body, has good kinetic properties, and is useful for preparing tissue anti-adhesion films. This polymer is composed of segments Aand Aeach having at least either of modified and unmodified amino acid groups, and segment B composed of PEG having a number average molecular weight of 8000 to 50000. The polymer contains both the modified and unmodified amino acid groups, the content of the modified amino acids is 20 to 85 mol % of all the amino acids in the polymer, and segment Ais bonded to one end of segment B and segment Ais bonded to the other end of segment B.

Polymer, bioabsorbable material and film for preventing tissue fusion

Process for producing (meth)acrylate derivatives

A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

Reactive vesicle and functional substance-fixed vesicle

The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

Polymers having benzeneboronic acid groups and insulin complexes of same

A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.

Phospholipid derivative and reactive vesicle-forming agent

Growing community of inventors

Tsukuba, Japan

Shigeru Kitano