Nippon Kayaku Kabushiki Kaisha

Shigeru Hasegawa

Nobuyoshi Shimada

Seiichi Saito

Akio Fujii

Hiroo Hoshino

Takayuki Tomizawa

Katsutoshi Takahashi

Masayuki Kitagawa

Kenichi Matsubara

Yukihiro Nishiyama

Takemitsu Nagahata

Takashi Harada

Jun-ichi Seki

Noriyuki Yamashita

Kyoichi Shibuya

Kaoru Matsuo

This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.

Oxetanocins

The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.

Antiviral phosphoric acid esters of oxetanocins

Oxetanocin G which is expectedly useful as an antiviral agent.

Oxetanocin G

This invention relates to oxetanocin-related compounds represented by the following formula (I): ##STR1## [in formula (I), R.sub.1, Y and B have the following meanings: (a) R.sub.1 represents --CH.sub.2 OH or --CH.sub.2 OCO-(alkyl),

Oxetanocin-related compounds and pharmaceutical compositions containing

The present invention provides a novel process for producing oxetanocin G by hydrolysis of alkoxylated 2-amino-oxetanocin A thereby to convert ##STR1## at the 6-position thereof into &gt;C.dbd.O. Oxetanocin G is expectedly useful as an antiviral agent.

Novel process for producing oxetanocin G

This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineo-plastic activities and is expected as a pharmaceutical as well as a process for the production of the same.

Novel antibiotic NK84-0218 and process for the production of the same

The present invention relates to a novel compound having hypoxanthine base represented by the following formula: ##STR1## as well as to use of said compound and process for producing said compound. The novel compound of the present invention has an immunosuppressive and antiviral actions and is expected to be useful as a medical drug.

Purine derivative

This invention relates to a novel antibiotic NK84-0218 of the formula: ##STR1## which exhibits antibacterial, antiviral and antineoplastic activities and is expected as a pharmaceutical as well as a process for the production of the same.

Growing community of inventors

Urawa, Japan

Shigeru Hasegawa