Tosoh Corporation

Shigeo Tsuchiya

Kiyoshi Yasukawa

Takahiko Ishiguro

Hiroshi Iida

Teruhiko Ide

Harutaka Yagame

Takahiro Maruyama

Toshinori Hayashi

Teiji Ekida

Noriyoshi Masuda

Takao Matsuba

The present invention intends to provide an IL-6R.IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker. The IL-6 receptor.IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.

Polynucleotide encoding IL-6 receptor/IL-6 fusion protein

The present invention intends to provide an IL-6R&#x2022;IL-6 fusion protein and the like in which IL-6R and IL-6 are directly linked without a linker. The IL-6 receptor&#x2022;IL-6 fusion protein of the present invention has a structure in which one amino acid residue constituting IL-6 receptor and one amino acid residue constituting IL-6 are directly bonded.

IL-6 receptor&#x2022;IL-6 direct fusion protein

An oligonucleotide, capable of specific cleavage and amplification of a pab gene which codes for pab, an antigenic protein of, or an RNA derived therefrom, as well as being useful in high sensitive detection and identification thereof, is provided. Further, a combination of oligonucleotides, useful in specific amplification, high sensitive detection and identification of an RNA derived frompab gene as well as a process for detectingby using said combination, are provided.

Oligonucleotides for detecting tubercle bacillus and method therefor

A method of assaying the efficacy and/or toxicity of a test substance by expression of a specific gene in a cell or a microorganism, which comprises treating the cell or the microorganism with the test substance, a step of amplifying an RNA having a sequence homologous or complementary to a specific sequence in a target RNA obtained as the result of transcription of the specific gene, and a step of determining whether the target RNA is transcribed through the expression of the specific gene by detecting the RNA amplified in the previous amplification step.

Method of evaluating drug efficacy and toxicity

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Kanagawa, Japan

Shigeo Tsuchiya