Sumitomo Chemical Company, Limited

Kao Soap Company, Ltd.

Shigeo Ogino

Shinichi Kojima

Ten Koide

Hideki Yanagi

Hisao Yamamoto

Takao Kiyohara

Noboru Yoshida

Masaru Fukui

Kazuro Nakamura

Junichi Yoshikawa

Yasuo Bai

Yoshito Kameno

Masaharu Kanaoka

Toshiro Tsuchiya

An acidic protease inhibitor obtained by allowing a compound of ##STR1## wherein X and Y are L-leucine or L-valine, or its salt, to react with an aluminum compound in a medium containing water and/or an alcohol, and further continuing the reaction after adjusting the pH of the system within a range of 4.5 to 7. The protease can stay long in stomach, have an action to protect ulcerated areas and retain the antiulcer effect for a long period of time.

Protease inhibitors

A method for purifying human growth hormone which comprises purifying an aqueous solution of crude human growth hormone by chromatography using a water-insoluble carrier having hydrophobic groups. High purity human growth hormone can be obtained by this hydrophobic interaction chromatography.

Purification of human growth hormone

Antiviral agents containing an effective amount of 1-amino-2,4-ethanobicyclo[3,3,1]nonane or salts thereof which are effective for the treatment or prevention of infectious diseases caused by herpes or influenza virus.

Antiviral agent

Antitumor substances are prepared by culturing a microorganism, Acinetobacter calcoaceticus. The antitumor substances have potent antitumor activity as well as immunostimulatory activity and are effective in a very small amount without harmful effects such as toxicity.

Novel anti-tumor substance and preparation thereof

Novel procidins effective for healing or preventing ulcers are produced and accumulated in the cultured product of a novel strain Streptomyces procidinanus.

A process for purifying urokinase by contacting a crude urokinase-containing solution with a strongly acidic cation exchanger having sulfonic acid groups and adjusted to the NH.sub.4.sup.+ type to adsorb urokinase on said cation exchanger and then eluting urokinase from said exchanger, characterized in that urea is previously added to the crude urokinase-containing solution in such a rate that the final molar concentration of urea in the solution is 3 to 8 M. This process is capable of providing purified urokinase having substantially constant and high specific activity from a crude urokinase-containing solution with a high recovery regardless of purity of the crude urokinase.

Process for purifying urokinase

4-Carbamoyl-5-hydroxyimidazole representable by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have been found to be useful as therapeutic agents for the treatment of rheumatism and nephritis.

Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole

Viral infections caused by viruses belonging to Herpes and Influenza groups can be controlled by administering an effective amount of 3-amino-4-homoisotwistane of the formula, ##STR1##

A process for purifying urokinase which comprises contacting a crude aqueous solution of urokinase with an ionic pullulan gel and thereafter separating and recovering an aqueous solution of urokinase devoid of harmful impurities.

Purification of urokinase

Novel procidins effective for healing or preventing ulcer are produced and accumulated in the cultured product of a novel strain Streptomyces procidinanus.

Growing community of inventors

Nishinomiya, Japan

Shigeo Ogino