Nippon Soda Co., Ltd.

Asubio Pharma Co. Ltd.

Daiichi Asubio Pharma Co., Ltd.

Shigeo Mori

Mitsuru Takase

Takahiro Sagae

Daisuke Asanuma

Noriaki Kawahara

Hiroyuki Yazaki

Toshiyuki Watai

The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

Processes for preparation of organic compounds

There is provided a method by which various compounds (1) having a carboxyl group in the molecule have the carboxyl group converted to a (dioxolenon-4-yl)methyl ester at low cost, in a simple way and at high yield. The process for producing compounds of formula (3) according to the reaction scheme shown below comprises reacting carboxylic acids of formula (1) with 4-chloromethyldioxolenone compounds of formula (2) in a solvent in the presence of both a phase transfer catalyst and a metal iodide: [where Q represents an organic group, M represents a hydrogen atom, an alkali metal, an alkaline earth metal or a transition metal, Rand Rrepresent a hydrogen atom, an optionally substituted (Calkyl group or phenyl group)].

Process for producing (dioxolenon-4-yl)methyl ester derivative

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Niigata, Japan

Shigeo Mori