Japan Air Curtain Company, Ltd.

Other

Astellas Pharma Gmbh

Tornex, Inc.

Shigeo Matsui

Tomoyuki Saito

Takafumi Shimizu

Shunichiro Matsumoto

Takatoshi Kanayama

Hiroaki Tanaka

Hideki Kubota

Kazuhiro Yokoyama

Naoto Katoh

Chiharu Mori

[Problem] To provide a compound useful as a MTand/or MTreceptor agonist. [Solution] The present inventors have studied on MTand/or MTreceptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MTand/or MTreceptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MTand/or MTreceptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence. 

Indole compound

The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R, R, R, R, R, R, Rand Rhave the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.

Indole carboxamide derivative

An air cleaning system having a forced negative pressure generating function is provided for defining a space in a room for utilizing the space as a smoking area or the like in which contaminated air such as smoke is prevented from flowing out of the space and is cleaned. The air cleaning system having a forced negative pressure generating function has an air curtain producing unit having a blow-out port for producing air curtains to surround a predetermined space, an air sucking unit having a suction port open to the predetermined space defined by the air curtains for sucking air in the predetermined space, an air exhausting unit having an exhaust port open to the outside of the predetermined space for exhausting air sucked by the air sucking means to the outside of the predetermined space, an air cleaner unit interposed between the exhaust port and the suction port, and an air cleaner body supported by a plurality of stems for accommodating the components. An amount of air exhausted from the exhausted port is set larger than an amount of air externally involved by the air curtains from the outside of the predetermined space to produce a negative pressure in the predetermined space defined by the air curtains. In this way, the negative pressure in the predetermined space prevents contaminated air such as smoke from leaking therefrom, and the air cleaner unit cleans such contaminated air before it is exhausted from the predetermined space.

Air cleaning system having forced negative pressure generating function

A space surrounded by screens to provide a stable negative pressure preventing contaminated air from flowing out of the space and cleaning the contaminated air before discharged from the space. Air ports and fans are provided in the screen.

Screen having an air cleaning function

An array of parallel pipes, each having ports through which jet-like air streams exit, are arranged so that a peripherally directed air curtain is formed. The posts are shielded at both ends, and one end is provided with a chimney along a central axis of the air by which air or fluid is removed. By giving the air curtain a centrifugal force, a negative pressure is produced along a central core, and a spiral flow is produced, creating an artificial tornado.

Growing community of inventors

Tokyo, Japan

Shigeo Matsui