Kanegafuchi Chemical Industry Co., Ltd.

Kaneka Corporation

Shigeo Hayashi

Noboru Ueyama

Satomi Takahashi

Kenji Inoue

Naoaki Taoka

Masakatsu Shibasaki

Junzo Hasegawa

Takehisa Ohashi

Masaru Mitsuda

Teruyoshi Koga

Optically active aminoalcohol derivatives and method of producing same

A novel 2,4-dihydroxyadipic acid derivative of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are the same or different and each a hydrogen atom, an alkyl group, an aralkyl group, an aryl group or a silyl group, and R.sup.2 and R.sup.3 are the same or different and each a hydrogen atom or a protective group of a hydroxy group or together form a ring, which is useful as a common intermediate in the synthesis of HMG-CoA reductase inhibitor.

2,4-dihydroxyadipic acid derivative

3-Pyrrolidinol or its salt is economically produced by cyclizing an aminobutanol derivative of the formula: ##STR1## wherein R is an alkyl or a substituted or unsubstituted phenyl group, or its salt.

Process for the preparation of 3-pyrrolidinols and intermediates therefor

A 3,4-epoxybutyrate of the formula: ##STR1## wherein R.sup.1 is an alkyl or aralkyl group is efficiently prepared by a process comprising steps of:

Process for the production of 3,4-epoxybutyrate and intermediate therefor

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Takasago, Japan

Shigeo Hayashi