Otsuka Pharmaceutical Company, Limited

Shigeo Fujieda

Naoto Utsumi

Minoru Okada

Koichi Shinhama

Masahiro Sota

Shin Ogasawara

Takashi Kabuki

Nao Koseki

The present invention provides a method for producing a compound of Formula (4): wherein Ris a hydrogen atom etc. by reacting a compound of Formula (2): wherein Xis a leaving group, with a compound of Formula (3): wherein Ris as defined above, in the presence of (a) a palladium compound and a tertiary phosphine or (b) a palladium carbene complex, in an inert solvent or without a solvent. The present invention can produce the compound of Formula (4), with high purity and high yield, and by a simple operation. 

Method for producing benzo[b]thiophene compound

An object of the present invention is to provide a novel method for producing an oxazole compound. The invention relates to a method for producing a compound represented by formula (1): wherein Ris lower alkyl group or halogen substituted lower alkyl group, Ris lower alkyl group, Ris lower alkyl group, Ris lower alkyl group, halogen substituted lower alkyl group or a group represented by formula: &#x2014;CYCOOR, wherein Y is a halogen atom, Ris an alkali metal atom or lower alkyl group, Aris phenyl group substituted with lower alkyl group, etc., or pyridyl group substituted with lower alkyl group, etc., X, Xand Xare the same or different and are halogen atoms, Xis a leaving group, and M is an alkali metal atom. 

Method for producing oxazole compound

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Osaka, Japan

Shigeo Fujieda