Mitsubishi Denki Kabushiki Kaisha

Astellas Pharma Gmbh

Toshiba Mitsubishi-electric Industrial Systems Corporation

Mitsubishi Denki K.k.

National Cancer Center

Shigenori Yagi

Masaki Kuzumoto

Youichiro Tabata

Shuji Ogawa

Koji Ohta

Yujiro Okihara

Noboru Wada

Koji Yasui

Akaru Usui

Norikazu Tabata

Hirozoh Kanegae

Hiromichi Komiya

Yuji Ganryu

Masaaki Tanaka

Takashi Yamamoto

Kazuki Kuba

Kenji Yoshizawa

Tateki Ozawa

Masahiro Mukai

Junji Ochi

Yoshinori Ishii

Akira Ishimori

Masazumi Kamohara

Yasuhito Myoi

Takanori Ueno

Mayumi Fujimura

Hiromi Nara

Nobuo Takeshita

Hiroki Sasaki

Junichi Nishimae

Yutaka Mihashi

Toshitaka Aoyagi

Masahisa Shinoda

Masayuki Komatsu

Akihiro Shima

Hiroki Shirai

Keisuke Namba

Morihiro Karaki

Yoshito Seiwa

Mitsuru Irie

Kazunori Hirayama

Yoshiyuki Tenda

Naoyuki Egusa

Toyohiro Uchiumi

Manabu Koike

Yasuyuki Satou

Masatoshi Yuri

Fumiko Chiwaki

Yoshiki Satake

Takeshi Utakouji

Shinji Endoh

Kazuhiko Maeda

An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer. An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD137 antibody binding to CD137 had agonistic activity for CD137, promoted production of interferon γ by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.

Anti-CLDN4/anti-CD137 bispecific antibody

Provided is an anti-human Tie2 antibody for preventing or treating diabetic macular edema, diabetic retinopathy, and critical limb ischemia by binding to a human Tie2 to activate the human Tie2. The present inventors have conducted investigations on an anti-human Tie2 antibody, and have thus provided an anti-human Tie2 antibody comprising four heavy chain variable regions and four light chain variable regions, in which the heavy chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 122 of SEQ ID NO: 2, the light chain variable region consists of the amino acid sequence of the amino acid numbers 1 to 113 of SEQ ID NO: 4, the one heavy chain variable region and the one light chain variable region constitute one antigen-binding site, and the antibody comprises four antigen-binding sites.

Anti-human tie-2 antibody

An ozonizer has a flat plate-shaped low voltage electrodea flat plate-shaped high voltage electrodefacing a main surface of the low voltage electrodeThe ozonizer also has a flat plate-shaped dielectricand a spacer for forming a discharge gapof a thin thickness in a laminating direction provided between the low voltage electrodeand the electrodean electrode cooling sheetprovided facing a main surface of the electrodeat a side opposite the discharge gapfor cooling the electrodeThe ozonizer also has a thermal conducting/electric insulating sheetsandwiched between the electrodeand the electrode cooling sheetAn alternating voltage is applied between the low voltage electrodeand the electrodeand a discharge is produced in the discharge gapinjected with oxygen gas to produce ozone gas.

Ozonizer

An ozonizer has a flat plate-shaped low voltage electrode, flat plate-shaped first and second high voltage electrodes facing the low voltage electrode, a first dielectric, and a first spacer, located between the low voltage electrode and the first high voltage electrode, a second dielectric, and a second spacer between the electrode and the second high voltage electrode. The ozonizer also has a first electrode cooling sheet facing the first high voltage electrode at a side opposite a first discharge gap, a second electrode cooling sheet facing the second high voltage electrode, a first thermally conducting and electrically insulating sheet sandwiched between the first high voltage electrode and the first electrode cooling sheet, and a second thermally conducting and electrically insulating sheet sandwiched between the second high voltage electrode and the second electrode cooling sheet.

An ozonizer has a flat plate-shaped low voltage electrode and a flat plate-shaped high voltage electrode facing a main surface of the low voltage electrode. The ozomzer also has a flat plate-shaped dielectric and a spacer forming a discharge gap in a laminating direction, located between the low voltage electrode and the high voltage electrode, a high voltage electrode cooling unit forming a cooling water passage insulated from the high voltage electrode inside the high voltage electrode. An alternating voltage is applied between the low voltage electrode and the high voltage electrode and a discharge is produced in the discharge gap, into which oxygen is injected, to produce ozone gas.

The ozonizer of this present invention is small in size, and capable of generating highly concentrated ozone with a high (generating) efficiency. A low voltage electrode includes a disc-shaped low voltage electrode main body facing a high voltage electrode and an extension at one side of the low voltage electrode main body, and the extensions are laminated in layers on a base via blocks, and a coolant inlet portion for supplying coolant to a coolant passage, a coolant outlet portion for exhausting coolant from the coolant passage, and an ozone gas outlet portion for exhausting ozone gas from the ozone gas passage pass through the extensions and the blocks, respectively, in a laminating direction of the discharge cells.

An ozonizer has a flat plate-shaped low voltage electrode, a flat plate-shaped high voltage electrodefacing a main surface of the low voltage electrode. The ozonizer also has a flat plate-shaped dielectricand a spacer for forming a discharge gapof a thin thickness in a laminating direction provided between the low voltage electrodeand the electrode, an electrode cooling sheetprovided facing a main surface of the electrodeat a side opposite the discharge gapfor cooling the electrode. The ozonizer also has a thermal conducting/electric insulating sheetsandwiched between the electrodeand the electrode cooling sheet. An alternating voltage is applied between the low voltage electrodeand the electrodeand a discharge is produced in the discharge gapinjected with oxygen gas to produce ozone gas.

There is provided a highly efficient and compact ozone generating apparatus in which a very short air gap of about 0.2 mm is formed at high accuracy. Non-discharge portions are dispersed and disposed to cover an entire discharge space, or a spacer is provided to form the non-discharge portion. Further, an elastic body is mounted on a back face of an electrode, thereby enhancing an air gap accuracy of the discharge space.

Ozone generating method

Ozone generating apparatus

The second harmonic wave of a solid laser light which is emitted from a second harmonic wave light source is divided into a plurality of laser beams by a diffraction grating. The divided laser beams are converged on a record carrier into a plurality of light spots by an optical head. Magnetic field generating coils for applying magnetic fields to the respective light spots in accordance with the recording signals from a signal line are disposed under the record carrier. Part of the solid laser light is reflected and input to a beam splitter. Since part of the light input to the beam splitter is taken out, a stabilizer controls the output of the solid laser light from the second harmonic wave light source, parallel recording/reproduction using the plurality of light spots which are arranged on the record carrier is enabled and the formation of the plurality of light spots is effectively controlled. Thus, a magneto-optical recording and reproducing apparatus which is capable of high-density recording and high-speed data transfer, which supplies a stable and accurate optical output, and which facilitates the control of the optical output is provided.

Magneto-optical recording and reproducing apparatus

A method for producing hydrogen peroxide by electrical discharge in a material gas in which oxygen concentration is not less than 0.5% and less than 13% is disclosed in the first aspect. In the second aspect, an apparatus for producing hydrogen peroxide having a plurality of electrical discharge chambers connected in series is disclosed. In the third aspect, an apparatus in which a material gas is recycled is disclosed. In the forth aspect, an apparatus having its electrodes covered with dielectric and an electrical discharge chamber which is cooled by a cooling member. In the fifth aspect, a method for producing hydrogen peroxide having a step of inactivating radical species produced by electrical discharges is disclosed. In the sixth aspect, an apparatus having a condensation tube coated with resin with low reactivity with hydrogen peroxide is disclosed. In the seventh aspect, an apparatus for, after producing hydrogen peroxide, mixing the exhaust gas and the air in order to remove danger of explosion is disclosed. A method and an apparatus for producing hydrogen peroxide in accordance with the present invention produces hydrogen peroxide safely and efficiently.

Method and apparatus for producing hydrogen peroxide

A laser oscillator includes a housing which seals a laser medium gas from the atmosphere, concave mirrors (or a set of concave and convex mirrors) positioned in the housing and having the laser medium gas therebetween, an apertured mirror positioned between the concave mirror and the other concave or convex mirror on a line connecting the spherical centers of the mirrors at a predetermined angle relative to the line, and a window through which a laser beam reflected by the apertured mirror is output from the housing. The apertured mirror has a curved reflective surface, thereby simplifying the optical system in the housing and increasing the system's reliability.

Laser oscillator having a curved mirror with a through-hole

A solid state laser apparatus comprises a laser medium having a pair of optically flat surfaces confronting to each other, and side surfaces intersecting the optically flat surfaces along an optical axis, the laser medium having a rectangular cross section; heat insulators adhered to the side surfaces of the laser medium; and reflective films for shielding the thermal insulators from pumping light. A solid state laser apparatus may comprise heat conductors bonded to the side surfaces of the laser medium, the heat conductors removing heat which occurs at bonding surfaces, the amount of removed heat from the side surfaces being smaller than that from the optically flat surfaces.

Solid state laser apparatus

Growing community of inventors

Hyogo, Japan

Shigenori Yagi