Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Takeda Chemical Ind., Ltd.

Shigenori Ohkawa

Masaomi Miyamoto

Seiji Miwatashi

Masaki Setoh

Naoyuki Kanzaki

Hiroyuki Kimura

Osamu Uchikawa

Tetsuya Tsukamoto

Masahiro Okura

Tetsuya Aono

Takayuki Doi

Kohji Fukatsu

Giichi Goto

Yasuyoshi Arikawa

Tadatoshi Hashimoto

Kouki Kato

Koichi Kato

Zen-ichi Terashita

Nobuhiro Fujii

Mika Goto

Naohisa Fukuda

Yoshihiro Kiyota

Masaki Setou

Kenichi Naruo

Shouzou Yamamoto

Masato Shimojou

Shoji Fukumoto

Shokyo Miki

Tomohiro Kawamoto

Ken-ichi Naruo

Mitsuru Kakihana

Yasuo Nagai

A PKB (Akt) activating agent comprising a compound represented by the formula (I): wherein Rand R: H, a hydrocarbon group or a heterocyclic group or Rand Rform a ring in cooperation with the adjacent carbon atom; R: H, a hydrocarbon group or a heterocyclic group; W: represents a group represented by the formulas: wherein ring A: an optionally substituted benzene ring; ring B: an optionally substituted 5- to 7-membered nitrogen-containing heterocycle; R: an aliphatic hydrocarbon group substituted with an aromatic group and further optionally substituted, or an acyl group containing an aromatic group; R: H, Calkyl or acyl; R: an aromatic group, an aliphatic hydrocarbon group or acyl; and X: O or S; Y: O, S or NH; and ring C: an optionally substituted benzene ring, or a salt or a prodrug thereof, and use of the activating agent in prevention or treatment of depression, anxiety, manic-depressive psychosis or PTSD are provided.

Antidepressant

A cannabinoid receptor modulator containing a compound represented by Formula (I) wherein, X is an oxygen atom, etc., Ris an optionally substituted acylamino group, ring Ais a benzene ring which may further have a substituent in addition to R, and ring B is an optionally substituted 5-membered heterocycle, or a salt thereof or a prodrug thereof.

Cannabinoid receptor modulator

(1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

Substituted 1,3-thiazole compounds, their production and use

Compounds represented by the formula: wherein Rand Rare hydrogen atom, a hydrocarbon group or a heterocyclic group, or Rand Rmay form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates a group represented by the formula: wherein Rindicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, Ris hydrogen atom, a Calkyl, or an acyl group, Rindicates a Caryl group, or salts thereof. The compounds have an excellent action to inhibit neurodegeneration as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as drugs for nerve degenerative diseases.

Benzofuran derivatives, their production and use

An optionally N-oxidized compound represented by the formula: wherein Rrepresents hydrogen, hydrocarbon, heterocycle, amino, acyl, Rrepresents an aromatic group, Rrepresents hydrogen, pyridyl, aromatic hydrocarbon, X represents oxygen, optionally oxidized sulfur, Y represents a bond, an oxygen, optionally oxidized sulfur, a group represented by the formula NR(Rrepresents hydrogen, hydrocarbon or acyl) and Z represents a bond or a divalent acyclic hydrocarbon, or a salt thereof has an excellent adenosine Areceptor antagonistic activity and is used as an agent for preventing or treating diseases related to an adenosine Areceptor. Furthermore, the compound (I) or a salt thereof has p38 MAP kinase inhibitory activity and TNF-&#x3b1; inhibitory activity and is used as an agent for preventing or treating diseases related to p38 MAP kinase and diseases related to TNF-&#x3b1;.

5-pyridyl-1,3-azole compounds, process for producing the same and use thereof

A compound represented by the formula: (wherein, Rand Rare the same or different and each represents a hydrogen atom, hydrocarbon group or heterocyclic group, or Rand Rmay form, together with the adjacent carbon atom, a 3&#x2013;8 membered iso- or heterocyclic group, Rrepresents a cyclic group, a hydroxy group, a mercapto group that may have oxo, or an amino group, Rrepresents a hydrogen atom, a hydrocarbon group, a hydroxy group, a mercapto group which may have oxo, or an amino group, or Rand Rmay link together to form a double bond, X represents a bond or a linear hydrocarbon group, W represents an oxygen atom or a sulfur atom, ring B represents a 5&#x2013;8 membered nitrogen-containing heterocyclic group, ring C represents a benzene ring, and&#x2014; represents a single bond or a double bond), or a salt or a prodrug thereof that has excellent neurodegenerative inhibitory activity and brain penetrability, and is useful as an agent for preventing/treating neurodegenerative diseases.

Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.

JNK inhibitor

Compounds represented by the formula:wherein Rand Rare hydrogen atom, a hydrocarbon group or a heterocyclic group, or Rand Rmay form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring, W indicates

A compound of the formula:wherein Rand Reach is H or a hydrocarbon group which may be substituted, or Rand Rform a 3- to 8-membered carbo or heterocyclic ring which may be substituted; Ris H, a lower alkyl which may be substituted or an aromatic group which may be substituted; Ris (1) an aromatic group which may be substituted, (2) an aliphatic hydrocarbon group substituted by an aromatic group which may be substituted, which hydrocarbon group may be further substituted or (3) an acyl; X and Y each is oxygen or sulfur which may be oxidized; and ring A is a benzene ring which may be further substituted, or a salt thereof, is useful for an agent for suppressing neurodegeneration.

Benzofurans as suppressors of neurodegeneration

A compound represented by the formula (I):

Dihydrobenzofuran derivatives, process for the preparing thereof and agents

A 1,3-thiazole compound substituted at the 5-position by a pyridyl group optionally having substituent(s) has a superior p38 MAP kinase inhibitory activity and TNF-&#x3b1; production inhibitory activity.

Method for inhibiting p38 MAP kinase or TNF-&#x3b1; production using a 1,3-thiazole

A compound represented by the formula:wherein Ring A is a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, Ring B is benzene ring which is further substituted, Ring C is a dihydrofuran-ring which may be further substituted and R is hydrogen atom or an acyl group or a salt thereof has an excellent lipid peroxidation inhibitory activity and is useful as a lipid peroxidation inhibitor.

Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents

A pharmaceutical composition for antagonizing adenosine at adenosine A receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.

Growing community of inventors

Takatsuki, Japan

Shigenori Ohkawa