Kyoto University

Nitto Pharmaceutical Industries, Ltd.

Noster Inc.

Toyota Jidosha Kabushiki Kaisha

Shigenobu Kishino

Jun Ogawa

Yasunori Yonejima

Tsuyoshi Goto

Teruo Kawada

Nobuyuki Takahashi

Sakayu Shimizu

Masayoshi Muramatsu

Masakazu Ito

Chikara Ohto

Kohey Kitao

Shusei Obata

Si-Bum Park

Hidekazu Kim

Tatsuya Sugawara

Takashi Hirata

A method for producing a hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from the genusin the soil and using fatty acid as a substrate is provided by the present invention. In addition, a novel rare fatty acid with utility value which is obtained by the production method is also provided.

Production method for rare fatty acid using novel enzyme, and novel rare fatty acid

The present invention provides a derivative of hydroxylated fatty acid which has a high content of hydroxylated fatty acid, and permits easy ingestion and easy handling, and a production method thereof. The present invention provides a method for producing a homopolymer of hydroxylated fatty acid, including polymerizing the hydroxylated fatty acid by using an enzyme. The homopolymer of hydroxylated fatty acid is stabilized. In addition, a novel, utilizable homopolymer of hydroxylated fatty acid obtained by this production method is also provided.

Hydroxylated fatty acid homopolymer and production method thereof

The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived fromand using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.

Method for producing rare fatty acid using novel enzyme, and novel rare fatty acid

The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived fromincluding lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.

Method for producing oxo fatty acid and rare fatty acid

The invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

Metabolism-improving agent comprising rare fatty acid

The present disclosure provides a novel aldehyde synthase gene having activity of synthesizing a medium-chain aldehyde. Such gene encodes a protein comprising the amino acid sequence as shown in SEQ ID NO: 2.

Aldehyde synthase gene, recombinant microorganism comprising the same, and method for producing alkane using the same

The present invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

This invention provides a recombinant microorganism into which an acyl-CoA reductase exhibiting excellent activity in a reduction reaction using acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding an acyl-CoA reductase comprising any of characteristic Common sequences 1 to 3 introduced into a host microorganism.

Recombinant microorganism and method for producing a substance using the same

The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

10-hydroxy-cis-12-octadecenoic acid alkyl ester and use thereof

The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

Triglyceride and use thereof

This invention provides a recombinant microorganism into which an acyl-CoA reductase exerting excellent activity in a reduction reaction involving the use of acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding a protein (a) or (b) below introduced into a host microorganism: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence having 70% or higher identity to the amino acid sequence of SEQ ID NO: 2 and having activity for synthesizing an aldehyde compound from acyl-CoA.

The present invention provides a metabolism improving agent comprising an oxo fatty acid having 18 carbon atoms and a carbonyl group at the 10- or 12-position, and/or a hydroxy fatty acid having 18 carbon atoms and a hydroxyl group at the 10- and/or 12-position(s), and use of the metabolism improving agent as a food, a pharmaceutical product and the like.

The present invention provides an intestinal tract-protecting agent, an agent for the prophylaxis or improvement of a disease caused by damage in intestinal tract barrier function, which contains hydroxylated fatty acid, particularly hydroxylated unsaturated fatty acid, having a hydroxyl group at the 10-position and/or the 12-position, which is an intermediate of the metabolism of unsaturated fatty acid by

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Kyoto, Japan

Shigenobu Kishino